肿瘤抗原MAGE-3CTL预测表位的计算机分子模拟研究  

Study of molecular models of predicted CTL epitopes derived from the tumor antigen MAGE 3

作　　者：贾正才[1] 吴玉章[1] 万瑛[1] 

机构地区：[1]第三军医大学基础医学部全军免疫学研究所,重庆400038

出　　处：《第三军医大学学报》2000年第10期937-939,共3页Journal of Third Military Medical University

基　　金：国家自然科学基金资助项目 !(3990 0 1 34)

摘　　要：目的　从理论上分析预测表位与HLA A2分子的结合情况及其为HLA A2限制性CTL表位的可能性。方法　应用计算机分子模拟的方法 ,建立MAGE 3 4个CTL预测表位的HLA A2结合三维结构和各多肽与HLA A2分子所形成复合物的三维结构。结果　 4个预测表位的三维结构完全符合HLA A2限制性CTL表位的结构要求 ,且都能与HLA A2分子结合。结论　 4个CTL预测表位为HLAObjective To analyze the binding of CTL epitope candidates to the HLA A2 molecule and the possibility of them being HLA A2 restricted CTL epitopes. Methods The molecular models of CTL epitope candidates bound to the HLA A2 molecule and of the HLA A2 peptide complex were established by computer molecular modeling. Results The three dimensional configurations of four HLA A2 binding peptides were compatible with those of HLA A2 restricted CTL epitopes and they could bind to HLA A2 molecule. Conclusion It is suggested that the four peptides may be the CTL epitopes restricted by HLA A2 molecule.

关 键 词：肿瘤抗原 MAGE-3 CTL表位 计算机分子模拟 

分 类 号：R730.3[医药卫生—肿瘤] R392.11[医药卫生—临床医学]