ER-α基因多态性与子宫内膜癌的相关性研究  

Association of ER-α gene polymorphism with endometrial carcinoma

作　　者：谷杭芝[1] 郑飞云[1] 王金仙[1] 

机构地区：[1]温州医科大学附属第一医院妇科,325000

出　　处：《浙江医学》2013年第17期1554-1556,共3页Zhejiang Medical Journal

基　　金：温州市科技计划项目(20070003)

摘　　要：目的探讨温州地区人群中ER-α基因MSP I多态性与子宫内膜癌遗传易感性的关系。方法应用聚合酶链式反应-限制性片段长度多态性分析技术,对48例子宫内膜癌患者和96例健康体检者进行ER-α基因MSP I多态性检测,并分析该基因多态性与子宫内膜癌发病风险的关系。结果 ER-α基因MSP I多态性位点基因型频率及等位基因频率在子宫内膜癌组分别为TT(58.3%)、CC(10.4%)、TC(31.2%);T(74.0%)、C(26.0%);对照组分别为TT(31.2%)、CC(24.0%)、TC(44.8%):T(53.6%)、C(46.4%),两组间比较均有统计学差异(均P<0.05),且子宫内膜癌组等位基因C频率低于对照组(P<0.01)。结论ER-α基因MSPⅠ位点多态性的存在可能与子宫内膜癌易感性有关,且ER-α基因野生型(TT)可能是子宫内膜癌的危险因素。Objective To assess the association of ER- α gene polymorphisms with endometrial cancer. Methods A case-control study was performed with 48 endometrial cancer patients and 96 matched controls. The ER-α-MSP I polymorphism sites were detected by using polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP）. The association between genotypes and endometrial cancer was estimated by odds ratios （ORs） and the 95% confidence intervals（Cls） calculated by unconditional logistic regression. Results The distribution frequency of genotype of ER-α-MSP I site in endometrial cancer patients and controls was TT： 58.3% and 31.2%, CC：10.4% and 24.0%, TC： 31.2% and 44.8%, respectively ; the frequency of allelic gene was T： 74.0% and 53.6%, C：26.0% and 46.4%, respectively. There were significant differences in genotype distributions between two groups （P〈0.05）, and the frequency of allelic C in endometrial cancer patients was lower than that of controls. Conclusion There may be association of ER-α -MSP I site polymorphism with susceptibility of endometrial cancer.

关 键 词：子宫内膜癌 ER—α基因多态性 易感性 

分 类 号：R737.33[医药卫生—肿瘤]