四会市鼻咽癌危险因素的调查分析  

Analysis for risk factors of nasopharyngeal carcinoma in Sihui City

作　　者：曹素梅[1] 柳青[2] 黄启洪 杨成武[2] 黄腾波[1] 

机构地区：[1]中山医科大学肿瘤中心流行病室,广东广州510060 [2]中山医科大学卫生统计学教研室,广东广州510060 [3]四会市肿瘤研究所,广东四会526200

出　　处：《癌症》2000年第11期987-989,共3页Chinese Journal of Cancer

基　　金：国家九五攻关项目基金!(No: 96- 906- 01- 03)资助

摘　　要：目的：分析四会市鼻咽癌的发病危险因素。方法：通过遗传流行病学的家系分析及病例对照研究，对四会市 1998年 1月至 1999年 6月新发的 57例鼻咽癌及配偶家系进行了环境和遗传因素的调查，应用 Li- Mantel- Gart和 Falconer法进行了分离比、遗传度的估算，应用 logistic回归筛选了环境危险因素。结果：该地区鼻咽癌的分离比为 0.055，属于多基因遗传方式。遗传度为 79.1％。单因素及多因素 logistic回归分析显示，遗传、吸烟及厨房与居室无分开是四会市鼻咽癌的危险因素。结论：遗传和环境因素的共同作用是四会市鼻咽癌高发的原因。Objective： The current study was designed to analyze risk factors of nasopharyngeal carcinoma in Sihui area.Methods： The circumstance and genetic factors were investigated with genetic epidemiology study of family analysis and case- control study in the 57 nasopharyngeal carcinoma (NPC) newly diagnosed from January 1998 to July 1999 and their spouse families in Sihui area.The segregation ratio and the hereditality of NPC were estimated by the method of Li- Mantel- Gart and Falconer methods and the circumstance risk factors were screened with logistic method. Results： The segregation ratio of NPC was 0.055 and the genetic model was belonged to polygenetics. The hereditality (h2) of NPC was 79.1％ . The regression of logistic analysis showed that smoking and the living room does not separate from kitchen were the risk factors of NPC. Conclusion： The NPC could be resulted from the genetic and circumtance factors together.

关 键 词：鼻咽肿瘤 遗传度 遗传流行病学 危险因素 

分 类 号：R73-3[医药卫生—肿瘤]