急性脑血栓形成及其高危人群血浆PC、PS、D-Dimer水平的测定  

The assessment of plasma levels of PC、PS and D Dimer in patients with acute cerebral thrombosis and a group has this risk factors

作　　者：钱进[1] 姜长斌[1] 袁百香 马晓露[2] 

机构地区：[1]大连医科大学附属一院神经内科,辽宁大连116011 [2]大连医科大学附属一院检验科,辽宁大连116011

出　　处：《中风与神经疾病杂志》2000年第5期308-309,共2页Journal of Apoplexy and Nervous Diseases

基　　金：辽宁省科学技术基金资助项目!(No96 2 0 82 )

摘　　要：目的　探讨蛋白 C(PC)、蛋白 S(PS)和 D-二聚体 (D- Dim er)对诊断脑血栓形成的血栓前状态的意义。方法　采用 APTT法、发色底物法和免疫过滤法检测脑血栓形成急性期、高危人群、对照组的血浆 PC、PS、D-Dim er的变化。结果　 3组间 PC、PS、D- Dim er水平有非常显著性差异。前两组间 PC、PS活性的差异无统计学意义 ,D- Dim er浓度有显著性差异。结论　脑血栓形成的高危人群处于血栓前状态 ,PC、PS、D- Dimer可作为实验室诊断脑血栓形成的血栓前状态的指标。Objective To assess the role that determined plasma levels of protein C(PC),protein S(PS) and D Dimer in subjects with prethrombotic state of cerebral thrombosis. Methods The PC、PS and D Dimer levels of 34 acute cerebral thrombosis,30 higher risk of cerebral thrombosis and 30 controls were measured by APTT、chromogenic and immunomentric flowthrough methods. Results The very significant differences of PC、PS and D Dimer among subjects of 3 groups. Between acute cerebral thrombosis and subjects at higher risk of cerebral thrombosis events,PC and PS indicated no significant differences,D Dimer expressed a statistically significant differences. Conclusions The subjects at higher risk of cerebral thrombosis events are in the prethrombotic state of cerebral thrombosis. PC、PS and D Dimer can be regarded as laboratorial diagnostic markers of prethrombotic state of cerebral thrombosis.

关 键 词：脑血栓形成 血栓前状态 PC PS D-DIMER 

分 类 号：R743.320.2[医药卫生—神经病学与精神病学]