碳酸酐酶IV自身抗体在慢性心力衰竭患者中的测定  

The Detection of Carbonic Anhydrase IV Auto-Antibody in Patients with Chronic Heart Failure

作　　者：刘辰庚[1] 王金玲[1] 李蕾[1] 张雁冰[1] 洪萍[1] 宋静[1] 王培昌[1] 

机构地区：[1]首都医科大学宣武医院检验科,北京100053

出　　处：《现代生物医学进展》2013年第25期4854-4856,共3页Progress in Modern Biomedicine

基　　金：教育部博士点基金(20121107110001)

摘　　要：目的:对慢性心力衰竭(CHF)患者血清中的抗碳酸酐酶IV自身抗体、抗氧化物及细胞因子的水平进行检测。方法:选取CHF患者共73例,测定其血清抗碳酸酐酶IV自身抗体、血沉、SOD等6种抗氧化物和IL-6等4种细胞因子的水平。结果:CHF患者血清抗碳酸酐酶IV自身抗体水平显著高于健康对照组(P<0.05),SOD、GPx、CAT和TAC水平显著低于健康对照组(P<0.05),MDA水平显著高于对照组(P<0.05)。CHF患者血清的IL-2水平较健康对照组显著升高(P<0.05),IL-3、IL-17、IFN-α和IFN-γ与健康对照组无显著性差异(P>0.05)。结论:CHF患者血清抗氧化物水平和IL-2的变化可能参与了其体内碳酸酐酶IV抗体的产生。Objective： To determine the carbonic anhydrase IV auto-antibody, the level of cytokines and antioxidants in the patients with chronic heart failure （CHF）. Methods： To determine the anhydrase IV auto-antibody, the level of 5 kinds of cytokines （IL-2, etc）, 6 kinds of antioxidants （SOD, etc） and erythrocyte sedimentation rate. Results： The level of anhydrase IV auto-antibody in CHF patients was significantly higher than those in the control group （P〈0.05）. The levels of SOD, GPx, CAT and TAC in CHF patients were significantly lower （P〈0.05） while MDA level was significantly higher （P〈0.05） than those in the control group. There was no significant difference of the levels of IL-3, IL-17, IFN-α and IFN-γbetween CHF patients and the control group （P〉0.05） while IL-2 level was sig- nificantly higher （P〈0.05） than those in the control group. Conclusion： The change of the levels of cytokines may take part in the genera- tion of carbonic anhydrase IV auto-antibody in CHF patients.

关 键 词：慢性心力衰竭 自身抗体 碳酸酐酶IV 细胞因子 抗氧化物 

分 类 号：R541.61[医药卫生—心血管疾病]