783例淋巴瘤患者流行病学分析  

Epidemiological analysis of 783 cases of lymphoma

作　　者：张欣[1] 王洁[2] 艾丽梅[2] 

机构地区：[1]辽宁医学院附属第一医院医学影像科,辽宁锦州121001 [2]辽宁医学院附属第一医院血液科

出　　处：《现代预防医学》2013年第20期3908-3912,共5页Modern Preventive Medicine

摘　　要：目的通过分析在某院诊治的淋巴瘤患者流行病学资料，探讨淋巴瘤的发病规律及临床特点。方法收集该院2002年1月1日～2011年12月31日收治的经病理证实为淋巴瘤的患者性别和年龄、病理类型、病变首发部位及实验室检查等资料，对发病特点、临床表现及疗效相关的数据进行统计分析。结果783例淋巴瘤患者中，男性多于女性，总体男女之比为1．72：1，年龄9～87岁，平均46岁，中位年龄43岁。病理类型以非霍奇金淋巴瘤（NHL）居多，与霍奇金淋巴瘤（HL）之比为5．21：1。其中126例HL以混合细胞型（44．44％）和结节硬化型（38．10％）为主，临床分期以Ⅲ期A组为主，占21．43％，结性起病占84．92％；657例NHL中弥漫大B细胞淋巴瘤最常见（38．10％），其次为黏膜相关淋巴组织淋巴瘤、滤泡淋巴瘤、周围T细胞淋巴瘤、间变大细胞淋巴瘤，临床分期以ⅣB为主，占16．29％，结性起病占43．22％，结外最常见部位为消化系统、Waldeyer环、鼻咽部及鼻腔。血LDH和β2-MG在晚期淋巴瘤患者中明显增高。结论该院淋巴瘤住院人数呈逐年增加的趋势，临床及病理学特点与国内外研究不尽相同，且HL和NHL在临床特点上亦存在一定差异。OBJECTIVE The study aimed to investigate the epidemic pattern and clinical features of lymphoma by analyzing the epidemiological data among lymphoma patients in our hospital. METHODS Clinical data, including gender and age, pathological type, earliest affected site, and laboratory test results, of pathology lab-confirmed lymphoma patients treated in our hospital between January 1, 2002 and December 31, 2011 were collected, and the morbidity pattern, clinical features, and effectiveness of the treatments were analyzed. RESULTS Among the 783 lymphoma cases, the number of male patients was higher than that of female patients, resulting in an overall male to female ratio of 1.72 ： 1 ; age of the patients ranged from 9-87 years old, with an average age of 46 and median age of 43. Non-Hodgkin lymphoma （NHL） was the most com- mon pathological type among the cases, with a NHL to Hodgkin lymphoma （HL） ratio of 5.21 ： 1. Among the 126 HL cases, 44.44% were of mixed cellularity type and 38.10% were nodular sclerosis HL; most of the patients were at Stage Ill Group A, accouting for 21.43% of the HL cases, and 84.92% of the onset involved lymph node lesion. Among the 657 NHL cases, the most prevalent pathological type was diffuse large B-cell lymphoma （38.10%） ; other common types included mucosa-associ- ated lymphoid tissue lymphoma, follicular lymphoma, peripheral T-cell lymphoma, and anaplastic large cell lymphoma; most patients were at Stage III Group B, accounting for 16.29% of the NHL cases, and 43.22% of the onset involved lymph node lesion. The most common extranodal sites included the digestive system, Waldeyer-ring, nasal sinus, and nasal cavity. Levels of serum lactic acid dehydrogenase （LDH） and β2-microglobulin （β2-MG） were significantly higher in advanced lymphoma patients. CONCLUSION The number of lymphoma patients hospitalized in our hospital is on the rise. Clinical and pathological features of the patients are shown to be different from related domestic and international research re

关 键 词：淋巴瘤 流行病学 调查分析 

分 类 号：R733.4[医药卫生—肿瘤]