舒血宁注射液辅助治疗脑出血疗效的Meta分析  

Meta-analysis of Therapeutic Efficacy of Shuxuening Injection in the Treatment of Cerebral Hemorrhage

作　　者：隋东明[1] 杨腾飞[1] 马超[2] 杨韧[1] 

机构地区：[1]中国医科大学附属盛京医院胃肠外科,沈阳110004 [2]中国医科大学附属第四医院神经内科,沈阳110004

出　　处：《中国药房》2013年第40期3805-3808,共4页China Pharmacy

摘　　要：目的:系统评价舒血宁注射液辅助治疗脑出血的临床疗效。方法:计算机检索中国期刊全文数据库、万方数据库、维普数据库、中国生物医学文献数据库网络版公开发表的舒血宁注射液辅助治疗脑出血的随机对照试验(RCT)和半随机对照试验,提取资料后采用Rev Man 5.2统计学软件进行Meta分析。结果:共纳入9项RCT,合计1 399例患者。Meta分析结果显示,治疗组患者治疗后的临床有效率[OR=2.22,95%CI(1.69,2.91),P<0.01]、治疗14 d后的脑血肿体积[WMD=-7.18,95%CI(-11.44,-2.91),P<0.01]都优于对照组患者,两组比较差异有统计学意义;但两组患者治疗14 d后的脑水肿体积比较差异无统计学意义[WMD=-2.64,95%CI(-6.03,0.75),P=0.13]。结论:舒血宁注射液辅助治疗脑出血疗效较好,并且可以显著缩小脑血肿体积。OBJECTIVE： To evaluate clinical efficacy of Shuxuening injection in the treatment of cerebral hemorrhage systemat- ically. METHODS： Retrieved from CNKI, Wanfang database, VIP and CBM online version, RCTs （QRCT）about therapeutic effi- cacy of Shuxuening injection in the treatment of cerebral hemorrhage were collected. Meta-analysis of included trials was performed using Rev Man 5.2 soRware. RESULTS： A total of 9 studies were included, involving 1 399 patients. Meta-analysis showed that the improvement of clinical symptoms [OR=2.22, 95%CI（1.69,2.91）, P〈0.01] and the change of hematoma volume in treatment group [WMD=-7.18,95%CI（-11.44,-2.91）, P〈0.01] were better than the control group after 14 d treatment; there was statis- tical significance. There was no statistical significance in the change of edema volume in both groups 14 d after treatment [WMD= -2.64, 95%CI（-6.03, 0.75）, P=0.13]. CONCLUSIONS： Shuxuening injection is effective in the treatment of cerebral hemor- rhage, and can significantly improve the clinical symptoms and hematoma volume.

关 键 词：舒血宁注射液 脑出血 META分析 

分 类 号：R743.34[医药卫生—神经病学与精神病学]