短效促性腺激素释放激素激动剂长方案的降调节模式与临床处理要点  

The down-regulation mode of short-acting GnRH agonist long protocol and clinical management

作　　者：叶虹[1] 

机构地区：[1]重庆市妇产科医院遗传与生殖研究所,重庆400013

出　　处：《生殖医学杂志》2013年第10期742-744,共3页Journal of Reproductive Medicine

摘　　要：短效促性腺激素释放激素激动剂（GnRH—a）长方案仍然是目前体外受精一胚胎移植（IVF—ET）助孕治疗中的“金标准”方案。自1984年GnRH—a应用于IVF领域后，已有大量研究证实了其有效性。与单纯促性腺激素（Gn）促排卵比较，GnRH—a长方案能有效抑制早发内源性黄体生成素（LH）峰，减少取消周期，改善卵泡同步化，增加获卵数，提高卵母细胞和胚胎质量，改善子宫内膜接受性，提高妊娠率等优点，但伴随的缺点是增加Gn量，延长治疗时间，增加卵巢过度刺激综合征（OHSS）风险，The short-acting GnRH agonist long protocol is still a standard protocol in IVF. The down-regulation mode of short-acting GnRH agonist long protocol mainly includes two aspects：firstly,it requires at least 14 days of down-regulation of GnRH agonist for complete suppression of estradiol prior to ovarian stimulation; secondly, the antral follicle counts may change during down-regulation. Therefore, down-regulation of GnRH agonist long protocol needs at least 14 days; and appropriate prolongation of short-acting GnRH agonist down-regulation could improve the synchronization of follicular development.

关 键 词：短效促性腺激素释放激素激动剂 降调节 体外受精 

分 类 号：R[医药卫生]