常规体外受精后多精受精发生对妊娠结局的影响  

Influence of polyspermy on pregnancy outcome during conventional in vitro fertilization

作　　者：王巍 吴福敢 马海兰 胡肖玲 陆敏玉 

机构地区：[1]广西桂平市人民医院生殖医学中心,广西桂平537200

出　　处：《生殖医学杂志》2013年第10期802-805,共4页Journal of Reproductive Medicine

基　　金：2010年广西贵港市科学研究与技术开发计划项目(贵科攻关1005010)

摘　　要：目的探讨常规体外受精(IVF)后多精受精发生对妊娠结局的影响。方法回顾性分析2010年3月至2012年12月在我中心行常规IVF助孕治疗的511个周期,根据受精情况有无3PN合子发生,将周期分为两组,A组:多精受精组(至少1个以上的3PN发生),B组:无多精受精组(无3PN发生),比较两组的临床及实验室资料。结果 A组人绒膜促性腺激素(HCG)日雌二醇(E_2)水平、获卵数、成熟卵率、2PN率、受精率、D_3优质胚胎率、可供移植胚胎率、种植率及临床妊娠率均高于B组,差异有统计学意义(P<0.05)。结论 IVF后多精受精的发生对胚胎种植率以及临床妊娠率没有显著影响,可能预示较好的IVF妊娠结局。Objective. To investigate Influence of polyspermy on pregnancy outcome during conventional in vitro fertilization （IVF） Methods. The data of 511 cycles of conventional IVF in our center from March 2010 to December 2012 were retrospectively analyzed. According to whether 3PN zygote occurrence, the cycles is divided into two groups.group A.at least one or more of the 3PN zygote occurrence, group B.without 3PN occurrence. The clinical and laboratory data were compared between the two groups. Results. The estradiol （E2） levels on HCG day, number of oocytes retrieved, mature oocytes ratio, 2PN rate, fertilization rate, quality embryo rate on Day 3, transplant embryo rate, implantation rate and clinical pregnancy rates in group A were significant higher than those in group B （P〈0.05）. Conclusions. The occurrence of polyspermy after IVF does not significantly affect the embryo implantation rate and clinical pregnancy rate. On the contrary,it may indicate better IVF pregnancy outcomes.

关 键 词：体外受精 多精受精 胚胎移植 妊娠结局 

分 类 号：R[医药卫生]