CD64在监测恶性血液病患者化疗后感染中的意义  

Significance of CD64 in monitoring of infection after chemotherapy in patients with hematologic malignancies

作　　者：吴志丹[1] 周剑波[1] 孟文俊[2] 

机构地区：[1]东南大学医学院附属江阴医院检验科,江苏江阴214400 [2]东南大学医学院附属江阴医院血液科,江苏江阴214400

出　　处：《实用肿瘤杂志》2013年第5期473-475,共3页Journal of Practical Oncology

摘　　要：目的探讨中性粒细胞CD64表达在恶性血液病化疗后并发感染中的诊断价值。方法选取恶性血液病患者136例,按临床表现和细菌学检测结果分成细菌感染组和非感染组,组内按白细胞(WBC)数<1.0×109/L、1.0～4.0×109/L、>4.0×109/L 3个水平分成3组。用流式细胞术检测CD64,同时检测外周血白细胞数量和C反应蛋白(CRP),应用受试者工作特征曲线(ROC曲线)评价CD64及CRP分别对感染的诊断能力。结果恶性血液病患者并发细菌感染组CD64水平明显高于非感染组,组内CD64差异无统计学意义(P>0.05)。ROC曲线分析,CD64指数分析对感染的诊断较CRP更可靠。结论中性粒细胞CD64表达可作为恶性血液病化疗后并发感染的早期诊断、判断病情的可靠指标,且CD64水平与WBC数量无相关性。Objective To investigate the expression of neutrophil CD64 in hematologic malignancies after chemotherapy in diagnosis of the concurrent infections. Methods 136 patients with hematologic malignancies were selected, according to the clinical manifestations and bacteriological test results, and divided into bacterial infected group and non-infected group, then each group was divided into three subgroups by leukocyte count 〈1.0×10^9/L、1.0～4.0×10^9/L、〉4.0×10^9/L. The CD64 was assayed by flow cytometry. The peripheral white blood cell count and C-reactive protein（CRP） were simultaneously detected. The capabilityies of CD64 and CRP in diagnosing infection were evaluated using ROC curve. Results CD64 in patients with bacterial infection in hematologic malignancies group was significantly higher than that in non-infected group, and there was no significant difference in the subgroups. ROC curve analysis, CD64 index analysis on the diagnosis of infection were more reliable than the CRP. Conclusion Neutrophil CD64 expression can be used as reliable indicator in concurrent infection with hematologic malignancies after chemotherapy for early diagnosis, determining the condition, and there is no correlation between the number of WBC and CD64 levels.

关 键 词：血液肿瘤 药物疗法 感染 CD64 流式细胞术 诊断 

分 类 号：R733[医药卫生—肿瘤]