真菌植物提取物体内抗小鼠S180作用及与环磷酰胺联合作用  

The Anti-cancer Effects in Vivo of Fungus Plant Extract on Transplanted Tumor S-180 in Mice and the Synergistic Effects with Cyclophosphamide

作　　者：原茵[1] 贺小琼[1] 王子睿[1] 姚乾[1] 

机构地区：[1]昆明医科大学公共卫生学院,云南昆明650500

出　　处：《昆明医科大学学报》2013年第9期16-19,共4页Journal of Kunming Medical University

基　　金：云南省科技计划项目(2009FXL001)

摘　　要：目的研究真菌植物提取物AMH-D的体内抗肿瘤作用,与环磷酰胺是否具有联合作用以及联合作用的形式和强度,为抗癌药物的开发提供科研基础.方法昆明种小鼠右腋皮下接种S-180肿瘤细胞,随机分组后,第2天开始腹腔注射给药,隔天给药1次,第11天处死小鼠,剥离并称重肿瘤,以肿瘤重量作为分析评价指标.结果提取物AMH-D能显著抑制S-180的生长,在剂量为150 mg/kg时抑瘤率达50.45%,其肿瘤抑制作用呈现剂量-效应关系.AMH-D对小鼠体重增长没有明显的影响.AMH-D与环磷酰胺具有体内协同抗肿瘤作用.结论真菌植物提取物AMH-D具有体内抑制S-180肿瘤作用,并与临床抗癌药物环磷酰胺具有体内联合抗癌作用.Objective Study the anti-tumor effects in vivo of AMH-D on S-180 cell lines, the synergistic effects of AMH-D and cyclophosphamide, and investigate the way and its strength of the effect. Provide the basis for the development of anti-cancer drug. Methods Kunming mice were transplanted with S-180 tumor cells subcutaneously in the right armpit. Intraperitoneal injection was done after randomization on the next day. Mice were killed on the eleventh day, and tumors were stripped and weighed. The tumor weight was used as indicator for analysis and evaluation. Results The results showed that AMH-D could effectively inhibit the growth of S180 cells transplanted tumor. The tumor inhibition rate was 50.45% at the dose of 150 mg/kg, with a dose-effect relationship. There were no obvious impacts on the growth of the weight of mice. The results showed that AMH-D had a synergistic effect combined with cyclophosphamide within a certain dose. Conclusion Fungus extract AMH-D has a great effect on anti-tumor in vivo of S180 cells transplanted tumor, and has a synergistic effect combined with cyclophosphamide within a certain dose.

关 键 词：真菌植物 体内抗癌 S-180 联合作用 环磷酰胺 

分 类 号：R730.2[医药卫生—肿瘤]