非酒精脂肪肝病患者ApoB/ApoA1比值与胰岛素抵抗的相关性研究  

Association of ApoB/ApoA-1 Ratio with Insulin Resistance in Patients with Non-alcoholic Fatty Liver Disease

作　　者：沈丽新[1] 侯君[1] 吴强鹏[1] 王红蓉 夏媛[2] 朱丽蓉[2] 段艳萍[3] 

机构地区：[1]攀枝花学院附属医院,四川攀枝花6170002 [2]昆明医科大学 [3]昆明医科大学形态学实验室,云南昆明650500

出　　处：《昆明医科大学学报》2013年第9期69-72,共4页Journal of Kunming Medical University

基　　金：地方高校国家级大学生创新创业训练计划资助项目(201210678002);昆明医科大学大学生创新性实验计划资助项目(CX201270)

摘　　要：目的探讨非酒精性脂肪肝病(NAFLD)患者载脂蛋白B(ApoB)/载脂蛋白A1(ApoA1)比值与胰岛素抵抗(IR)的相关性.方法纳入224例NAFLD患者和166例正常对照,测量身高、体重、血压,测定空腹血清葡萄糖(FPG)、胰岛素(Fins)、血脂和糖化血红蛋白(HbA1c)等,计算IR指数(HOMA-IR).结果与正常对照比较,NAFLD患者ApoB/ApoA1比值(0.76±0.28)vs(0.61±0.26)和HOMA-IR(2.43±1.68)vs(1.86±1.61)明显升高.Spearman相关分析显示,NAFLD患者HOMA-IR与年龄、体质指数(BM)I、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-c)、ApoB/ApoA1比值(r=0.34,P<0.05)和HbA1c呈正相关,与高密度脂蛋白胆固醇(HDL-c)呈负相关.多元线性回归分析进一步校正年龄和BMI后,ApoB/ApoA1比值是NAFLD患者HOMA-IR的独立影响因素(R2=0.28,P<0.05).结论 NAFLD患者ApoB/ApoA1比值与IR的关系密切,提示ApoB/ApoA1比值可能参与了NAFLD患者IR的发生.Objective This study aims to investigate the association of apoB/apoA-1 ratio with insulin resistance （IR） in patients with non-alcoholic fatty liver disease （NAFLD） Methods A total of 224 patients with NAFLD and 166 healthy subjects were enrolled as NAFLD group and control group. Weight, height and blood pressure were recorded. Serum levels of fasting blood glucose （FPG） , insulin （Fins） , lipids, glycated hemoglobin （HbAlc） were measured. Homeostasis model assessment-insulin resistance （HOMA-IR） indices were calculated. Results Compared with control group, NAFLD group had higher apoB/apoA-1 ratio （0.76 士 0.28 vs 0.61 士 0.26） and HOMA-IR （2.43 士 1.68 vs 1.86 士 1.61） . Spearman correlation analysis showed that in NAFLD group, HOMA-IR positively correlated with age, body mass index （BMI） , triglycerides （TG） , low-density lipoprotein cholesterol （LDL-c） , apoB/apoA-1 ratio （r =0.34, P 〈 0. 05） and HbAlc, and negatively correlated with high-density lipoprotein cholesterol （HDL-c） . Multiple linear regression analysis revealed that apoB/apoA-1 ratio was still associated with HOMA-IR in NAFLD group after adjustment for age and BMI. Conclusion The apoB/apoA-I ratio is closely associated with IR in patients with NAFLD. ApoB/apoA-I ratiomay play a role in the development of IR in NAFLD.

关 键 词：非酒精性脂肪肝 载脂蛋白B 载脂蛋白A1比值 胰岛素抵抗 

分 类 号：R575.5[医药卫生—消化系统]