DFY-Ⅱ超声图像定量分析仪评价兔VX_2肝癌治疗效果  

Treatment Effect Evaluation of Rabbit VX_2 Liver Carcinoma with DFY-Ⅱ Ultrasound Imaging Analysis Software

作　　者：康娟[1] 吴小翎[2] 屈健宁[2] 张大志[1] 郑元义[3] 王志刚[3] 

机构地区：[1]重庆医科大学附属第二医院肝病治疗研究中心,重庆市400010 [2]重庆医科大学附属第二医院消化内科,重庆市400010 [3]重庆医科大学附属第二医院超声影像学研究所,重庆市400010

出　　处：《中国超声医学杂志》2013年第10期937-941,共5页Chinese Journal of Ultrasound in Medicine

基　　金：国家自然科学基金重点项目(No.81130025);国家自然科学基金青年科学基金项目(No.30900370);重庆市自然科学基金项目(No.cstc2012jjA0158)

摘　　要：目的探讨DFY-Ⅱ型超声定量分析仪在评价肝癌治疗效果中的临床应用价值。方法 60只VX_2肝癌兔随机分为6组,对处理前后的声像图做定量分析,免疫组化法检测处理后CD34的表达并计数微血管密度(MVD),分析处理后灰阶值与MVD的相关性,比较各组处理前后的灰阶值并分析治疗效果与灰阶值变化的关系。结果处理后载多西紫杉醇脂质微泡+超声(LMLD+US)组的灰阶值和MVD明显低于其他组(P<0.01),LMLD+US组的效果最佳;处理后各组灰阶值与MVD呈显著正相关(相关系数0.907)。结论定量分析仪所测得的灰阶值越高效果越差,灰阶值越低效果越好,定量分析的结果能反映治疗效果,定量仪在评价肝癌治疗效果中具有潜在的临床应用价值。Objective To study the clinical value of DFY- Ⅱ ultrasound imaging analysis software in effect esti- mation of liver carcinoma. Methods 60 model rabbits were randomly divided into 6 groups. Ultrasonic imaging pictures were captured before and after treatment, the grey scales were quantitively analyzed with DFY-Ⅱ ultrasound im aging analysis software, the expression of CD34 and microvessel density （MVD） were detected by immunohistochemistry, the correlation between gray scale and MVD after treatment was analyzed, the relationship between treatment effect and gray scale change was estimated. Results The grey scale value of all groups has no significant difference be fore treatment. After treatment, the grey scale value of LMLD＋US group was the lowest among all groups（P〈0.01）, the MVD of LMLD--US group was also the lowest among all groups（P〈0.01）, the grey scale values were positively correlated with MVD （r=0. 907）. Conclusions The result of quantitive analysis showed that the treatment effect gradually turned better with the decrease of grey scale values, quantitive analysis with DFY-Ⅱ ultrasound ima ging analysis software could reflect the treatment effect, DFY-Ⅱ ultrasound imaging analysis software has potentially clinical value in treatment effect estimation of liver carcinoma.

关 键 词：DFY-Ⅱ型超声定量仪 肝癌 超声微泡 微血管密度 

分 类 号：R735.7[医药卫生—肿瘤]