Wnt信号调控胶质瘤或胶质瘤干细胞增殖及迁移作用的研究进展  

Research progress on Wnt signaling in regulating proliferation and migration of glioma and glioma stem cells

作　　者：何东杰[1] 胡静[2] 魏丽春[2] 

机构地区：[1]第四军医大学唐都医院放射治疗科,陕西西安710038 [2]第四军医大学西京医院放射治疗科,陕西西安710032

出　　处：《现代肿瘤医学》2013年第10期2354-2358,共5页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(编号:81272346;30970862)

摘　　要：近年研究发现Wnt信号通路与神经胶质瘤及其肿瘤干细胞的细胞增殖及细胞迁移相关,Wnt信号蛋白及其关键家族成员的表达水平与胶质瘤恶性程度密切有关,提示Wnt信号及相关通路的靶干预可能成为恶性胶质瘤治疗的新途径。Growing studies in recent years have shown that Wnt signaling pathways might be involved in proliferation and migration of glioma cells and glioma stem cells. The expression levels of Wnt family proteins or Wnt signaling pathways were closely related to glioma grade malignancy, suggesting that Wnt signaling and related pathways may be- come potential intervention target for malignant glioma treatment.

关 键 词：神经胶质瘤 肿瘤干细胞 WNT信号 细胞增殖 细胞迁移 

分 类 号：R730[医药卫生—肿瘤]