PTPRO基因甲基化与肿瘤的研究进展  

Study on the association between PTPRO gene methylation and tumors

作　　者：李少英[1] 吴华聪[1] 罗荣城 

机构地区：[1]深圳市宝安区妇幼保健院,广东深圳518133 [2]广州南方医院肿瘤科,广东广州510515

出　　处：《现代肿瘤医学》2013年第10期2370-2373,共4页Journal of Modern Oncology

基　　金：深圳市科技计划项目(编号:201103049);深圳市宝安区科技计划社会公益项目(编号:20110634)

摘　　要：PTPRO基因是蛋白酪氨酸磷酸酶PTPs家族成员之一,是细胞增殖、分化、代谢、细胞与细胞间通讯、基因转录以及细胞存活等重要信号通路的媒介,参与细胞生长、分化、分裂周期、癌基因转化等多种过程,是新近发现的一个潜在抑癌基因,其在癌症发生机制中的作用是目前研究的热点。多项研究发现在多种恶性肿瘤组织中均存在PTPRO基因低表达,而且与其甲基化水平呈负相关,并指出PTPRO基因甲基化状态的检测具有重要的临床意义,有望成为临床早期诊断及疾病监控的生物学指标,而逆转PTPRO基因的甲基化则可能为癌症治疗提供新的方向。因此,PTPRO基因甲基化在肿瘤的发生发展过程中发挥着重要作用。PTPRO gene is a member of the family of receptor -type protein tyrosine phosphatases （PTPs）. It is an important signaling medium that can affect various cellular processes, including proliferation, differentiation, metabo- lism,communication, transcription, survival, contact inhibition, cell cycle and oncogene transformation. PTPRO has been described as a new potential tumor suppressor gene in many recent hot researches on carcinogenesis. Previous studies demonstrated methylation - mediated down - regulation of PTPRO expression in several forms of cancer. Some of them reported the potential clinical role of PTPRO gene methylation as biomarker for early diagnosis and disease monitoring. Demethylation of PTPRO gene might provide a new therapeutics for cancers. Therefore, PTPRO gene meth- ylation plays an important role during the occurrence and development of tumors.

关 键 词：编码膜结合受体型蛋白酪氨酸磷酸酶O（PTPRO） 甲基化 肿瘤 进展 

分 类 号：R730[医药卫生—肿瘤]