Preparation and characterization of doxorubicin functionalized tiopronin-capped gold nanorods for cancer therapy  

作　　者：HUO ShuaiDong JIN ShuBin ZHENG KaiYuan HE ShengTai WANG DongLiang LIANG XingJie 

机构地区：[1]CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety,National Center for Nanoscience and Technology [2]School of Materials Science and Engineering,Tianjin Polytechnic University

出　　处：《Chinese Science Bulletin》2013年第33期4072-4076,共5页

基　　金：supported by the National Natural Science Foundation of China(30970784,81171455 and 31100720);National Basic Research Program of China(2009CB930200);Chinese Academy of Sciences(CAS)"Hundred Talents Program"(07165111ZX);CAS Knowledge Innovation Program and Tianjin Research Program of Applied Basic&Cutting-edge Technologies(09JCYBJC27200)

摘　　要：Gold nanomaterials are immerging candidates in medical diagnosis and treatment.Among them,gold nanorods(Au NRs)are widely used for cancer treatment.Tiopronin as a novel thiol drug was used to stabilize Au NRs in this work.Doxorubicin(DOX),a chemotherapeutic drug which works by interacting with DNA to arrest the cell cycle and induce apoptosis,was linked to Au NRs through electrostatic reaction with tiopronin,to obtain Au-TIOP-DOX NRs.Au NRs are also regarded as hyperthermia agents for photothermal cancer treatment.This delivery system(Au-TIOP-DOX NRs)was designed for passively targeting tumor cells in cancer therapy.More importantly,the carboxyl groups of tiopronin can be modified with some biological molecules(DNA/RNA,peptides,or drugs)to make Au NRs as a novel drug-delivery system for cancer treatment.Gold nanomaterials are immerging candidates in medical diagnosis and treatment. Among them, gold nanorods （Au NRs） are widely used for cancer treatment. Tiopronin as a novel thiol drug was used to stabilize Au NRs in this work. Doxorubicin （DOX）, a chemotherapeutic drug which works by interacting with DNA to arrest the cell cycle and induce apoptosis, was linked to Au NRs through electrostatic reaction with tiopronin, to obtain Au-TIOP-DOX NRs. Au NRs are also regarded as hyperthermia agents for photothermal cancer treatment. This delivery system （Au-TIOP-DOX NRs） was designed for passively targeting tumor cells in cancer therapy. More importantly, the carboxyl groups of tiopronin can be modified with some biological molecules （DNA/RNA, peptides, or drugs） to make Au NRs as a novel drug-delivery system for cancer treatment.

关 键 词：癌症治疗 硫普罗宁 纳米棒 黄金 阿霉素 功能化 自然保护区 化疗药物 

分 类 号：R730.5[医药卫生—肿瘤]