岩舒注射液联合化疗对晚期胃癌患者生活质量的影响  

Effect of Yanshu injection combined with chemotherapy on quality of life in patients with advanced gastric cancer

作　　者：许进秀 王爱蓉[1] 王文静[1] 

机构地区：[1]山东省威海市立医院肿瘤医院,威海264200

出　　处：《中国肿瘤临床与康复》2013年第9期1043-1046,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的观察岩舒注射液（复方苦参注射液）联合化疗对晚期胃癌患者生活质量的改善及安全性的影响。方法将120例晚期胃癌患者随机分为观察组和对照组,每组60例。对照组患者采用FOLFOX方案常规化疗。观察组患者在对照组化疗方案基础上,同时加用岩舒注射液15ml入0.9%氯化钠注射液250ml静滴,每天1次,10d为1个疗程。2~6个周期化疗后进行疗效评价。观察两组患者生活质量评分、卡氏评分、疼痛评估、免疫功能和不良反应。结果生活质量评分、卡氏评分：观察组疗效优于对照组,差异有统计学意义（P〈0.05）。疼痛评估：观察组疼痛缓解率明显高于对照组（P〈0.01）。免疫指标：治疗前两组患者四项免疫功能水平无明显差异,观察组化疗前后各指标变化差异无统计学意义（P〉0.05）;对照组化疗后CD3、CD4、CD4/CD8指标均较化疗前明显下降,CD8上升,差异有统计学意义（P〈0.01）。两组治疗后各指标差异有统计学意义（P〈0.01）。观察组患者化疗后出现的不良反应大多较对照组少且程度减轻,差异有统计学意义（P〈0.05）。结论岩舒注射液配合化疗治疗晚期胃癌,能改善生活质量,缓解疼痛,增强机体免疫功能,降低化疗药物不良反应。Objective To observe the effect of Yanshu injection combined with chemotherapy on the improvement of quality of life and safaety in patients with advanced gastric cancer. Methods 120 cases of advanced gastric cancer were randomly divided into observational group （60 cases） and control group （60 cases）. The control group ordy received FOLFOX scheme, The observational group received FOLFOX scheme combined with Yanshu injection, Yanshu injection 15ml into the 0. 9% NS 250ml intravenous drip per day, and 10 days as a cycle. After 2-6 cycles of chemotherapy, the effective and side effect would be e- valuated. To observe the quality of life of two groups, KPS, pain assessment,immune function and adverse reaction. Results As to observational group, the quality of life, KPS, release of pain, and immunologic indexes were all better than control group （ P 〈 0.05 ）. Side effects in observational group is mild and much less than in control group （ P 〈 O. 05）. Conclusions Yanshu injection combined with chemotherapy can improve the quality of life, relieve pain, enhance immune function, reduce the adverse reaction of chemo- therapy in the treatment of advanced gastric cancer.

关 键 词：晚期胃癌 生活质量 岩舒注射液 药物疗法 

分 类 号：R735.2[医药卫生—肿瘤]