幼年和老年大鼠学习中海马CA_3区长时程突触增强的年龄特征  

THE AGE CHARACTERISTICS OF THE LONG-TERM SYNAPTIC POTENTIATION IN THE CA3 REGION OF HIPPOCAMPUS OF THE YOUNG AND THE AGED RATS DURING THE LEARNING

作　　者：李君[1] 许世彤[1] 区英琦[1] 

机构地区：[1]华南师范大学

出　　处：《Zoological Research》1991年第3期285-291,共7页动物学研究（英文）

基　　金：国家自然科学基金资助项目

摘　　要：研究发现幼年和老年大鼠在条件性饮水反应的建立、消退和再建立过程中,海马CA_3区有习得性长时程突触增强(LTP)的形成、消退和再形成现象。在它的形成和再形成以及每实验日训练作业后习得性LTP的发展上,幼年鼠明显快于老年鼠,而习得性LTP的消退,在两组间无明显差异。这既表明海马CA_3区的习得性LTP具年龄特征,也为论证习得性LTP可能是学习和记忆的神经基础之一提供了新的证据。The learning-dependent long-term potentiation (LTP) in the hippocampal CA3 region of the young and aged rats all was changed obviously during the establishment, extinction and re-establishment of conditioned drink response. The velocity of establishment and development of the learning-dependent LTP in CA3 of the young rats is more than that of the aged rats. However there was nonsignificant difference in the extinction of the learning-dependent LTP in CA3 of the young and the aged rats. These results not only showed that there was the age characteristics of the learning-dependent LTP in the CA3 region but also provided a evidence that the learning-dependent LTP might be one of the neural bases of learning and memory.

关 键 词：大鼠 学习 海马CA3区 长时程突触 

分 类 号：Q959.837[生物学—动物学]