光度法研究双醋瑞因与环糊精的包合作用  

Study on the inclusion between diacerein and cyclodextrin by spectrophotometry

作　　者：高苏亚[1,2] 李华[2] 郭林新[1] 刘鑫[1] 刘常军[1] 张航[1] 程芳[1] 戴佳伶 

机构地区：[1]西安医学院药学院,陕西西安710021 [2]西北大学分析科学研究所,陕西西安710069

出　　处：《应用化工》2013年第10期1751-1753,共3页Applied Chemical Industry

基　　金：国家自然科学基金资助项目(20975081);省级大学生创新训练计划项目(201211840005)

摘　　要：在模拟生理条件下,采用光度法研究双醋瑞因(DA)与β-环糊精(β-CD)和羟丙基-β-环糊精(HP-β-CD)的包合作用。由热力学参数Δr H m<0,Δr G m<0,说明DA与β-CD发生了一个放热、自发的结合过程;同时ΔrSm<0,ΔrHm<0,说明DA与β-CD之间的结合主要是氢键和范德华力;Δr G m<0与Δr H m>0,表明DA与HP-β-CD的包结过程是一个自发、吸热的过程,同时ΔrSm>0,ΔrHm>0,说明DA与HP-β-CD的结合主要是一熵驱动下的疏水作用过程。DA与β-CD和HP-β-CD之间的包合比均为1∶1,DA与HP-β-CD的结合常数大于同温度下与β-CD的结合常数。The inclusions between diacerein and beta-cyclodextrin （β-CD） and hydroxypropyl-beta-cyclo- cextrin （HP-β-CD） were investigated by spectrophotometry at the physiological conditions. A spontane- ous exothermic process was produced in the reaction of diacerein and β-CD according to thermodynamic parameters such as △rHm 〈 0 and △rGm 〈 0. Furthermore, it was concluded that diacerein interacted mainly with β-CD by hydrogen bond and Van Der Waals force according to thermodynamic parameters such as △rHm 〈 0 and △rSm 〈 0. At the same time, it was concluded that a spontaneous endothermic process was produced in the reaction of diacerein with HP-fl-CD according to thermodynamic parameters such as △rHm 〉 0 and △rGm 〈 0. In addition, it was a hydrophobic interaction process by entropy driving according to thermodynamic parameters such as △rHm 〉 0 and △rSm 〉 0 in the reaction of diacerein and HP-β-CD. The results were in agreement with the experimental ones. The ratios of inclusion were all 1 ： 1 in diacerein with β-CD and HP-β-CD. And the bonding constant in diacerein-HP-β-CD system was more than the one in dicerein-β-CD system at the same temperature.

关 键 词：双醋瑞因 光度法 环糊精 包合作用 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.3[化学工程—制药化工]