缺血性脑卒中患者血清HbA1c、hs-CRP及中医证型相关性  

Correlation Research between Serum HbA1c,hs-CRP and TCM Syndrome Types in the Patients with Ischemic Cerebral Stroke

作　　者：刘旭强[1] 

机构地区：[1]天津中医药大学

出　　处：《山西中医》2013年第10期50-52,共3页Shanxi Journal of Traditional Chinese Medicine

摘　　要：目的:观察缺血性脑卒中患者血清HbA1c、hs-CRP及中医证型相关性。方法:将320例诊断为缺血性脑卒中研究个体按初发与复发分为急性缺血性脑卒中初发组(A组)与复发组(B组),并进一步比较和分析两组间HbA1c与hs-CRP水平差异;按中风病证候诊断标准将缺血性脑卒中患者分为风痰火亢证、风痰瘀阻证、气虚血瘀证、阴虚风动证四证型,分析和比较A组与B组不同证型发病差异;分析和比较四组间HbA1c、hs-CRP水平的差异。结果:急性缺血性脑卒中初发组(A组)与复发组(B组)的中医证型分布差异(u=2.261 8,P=0.024 1)有显著性意义。初发组(A组)hs-CRP参数低于复发组(B组)(u=-2.616 7,P=0.009 5)。缺血性脑卒中患者不同证型组血清HbA1c水平高低顺序依次为:风痰瘀阻证>气虚血瘀证>风痰火亢证>阴虚风动证。缺血性脑卒中患者不同证型组hs-CRP水平高低顺序依次为:风痰火亢证>阴虚风动证>风痰瘀阻证>气虚血瘀证,且气虚血瘀证明显低于风痰火亢证(u=-2.728 5,P<0.01)。结论:缺血性脑卒中患者血清HbA1c、hs-CRP水平与初发组、复发组存在关联关系,与中医证型分布存在关联关系。Objective： To observe the correlation between serum HbAlc and hs -CRP in the patients with ischemic cerebral stroke and TCM syndrome. Methods： 320 cases with ischemic cerebral stroke were divided into onset group （group A） and relapse group （group B） according to ischemic stroke in primary or in recurrent. HbA1 c and hs - CRP were compared with in the two groups. According to the diagnostic criteria of syndrome differentiation, the cases were divided into four syndrome types, which were syndrome of wind - phlegm - fire hyperactivity, syndrome of wind-phlegm-stasis syndrome, syndrome of qi deficiency and blood stasis, and syndrome of yin deficiency and wind stirring. The onset differences in group A and group B were analyzed and compared as well as HbAlc and hs-CRP in the four syndrome types. Results： TCM syndrome distribution difference was statistically significant between the two groups （u =2. 261 8, P =0. 024 1 ）. hs-CRP in group A was lower than that in group B （ u = - 2. 616 7, P = 0. 009 5 ）. Serum HbA1 c order in different syndrome types of ischemic stroke was that as the sequence from high to low- syndrome of wind - phlegm - stasis syndrome, syndrome of qi deficiency and blood stasis, syndrome of wind - phlegm - fire hyperactivity, and syndrome of yin deficiency and wind stirring, hs - CRP order was that also as the sequence from high to low- syndrome of wind - phlegm - fire hyperactivity, syndrome of yin deficiency and wind stirring, syndrome of wind - phlegm - stasis, and syndrome of qi deficiency and blood stasis. And the difference was statistically significant too between syndrome of qi deficiency and blood stasis and syndrome of wind - phlegm - fire hyperactivity （ u = - 2. 728 5, P 〈 0.01 ）. Conclusion： HbAlc is associated to hs -CRP in the patients with ischemic cerebral stroke between primary groups and recurrent group. And they were related to the distribution of TCM syndromes.

关 键 词：缺血性脑卒中 糖化血红蛋白 高敏C反应蛋白 

分 类 号：R743.3[医药卫生—神经病学与精神病学]