喉癌组织中Survivin表达及其临床意义的Meta分析  

Expression and Clinical Significance of Survivin in Tissues of Laryngeal Carcinoma in China: A Meta-Analysis

作　　者：李泽文[1] 周洁[1] 何源萍[1] 严福波[1] 杨志敏 丁珠华 

机构地区：[1]孝感市中心医院耳鼻咽喉科湖北孝感432100 [2]孝感市第一人民医院五官科湖北孝感432100

出　　处：《中国循证医学杂志》2013年第10期1200-1208,共9页Chinese Journal of Evidence-based Medicine

摘　　要：目的应用Meta分析方法评估国内有关喉癌组织中Survivin表达及临床意义的研究。方法计算机检索CBM(1994～2012.10)、CNKI(1994～2012.10)、VIP(1989～2012.10)和WanFang Data(1996～2012.10),收集中国公开发表的关于喉癌组织中Survivin表达及其与临床病理特征关系的病例-对照研究。按纳入和排除标准筛选文献、提取资料并评价纳入研究质量后,应用RevMan 5.1软件进行Meta分析。结果共纳入25个病例-对照研究,其中喉癌1 333例,正常喉黏膜或声带息肉528例。Meta分析结果显示:Survivin在喉癌组与对照组、喉癌无淋巴结转移组与淋巴结转移组、临床Ⅰ～Ⅱ期组与临床Ⅲ～Ⅳ期组、高分化组与中、低分化组、T1和T2期组与T3和T4期组、声门型喉癌组与非声门型喉癌组的表达差异均有统计学意义(P<0.05);Survivin在≥60岁喉癌组与<60岁组、男性喉癌组与女性组、吸烟组与不吸烟组表达差异则无统计学意义(P>0.05)。结论现有的国内证据证明,Survivin可能参与了喉癌发生、发展、转移的全过程,与肿瘤的恶性程度呈正相关,可能是预后不良的指征。Objective To evaluate the expression and clinical significance of Survivin in the tissues of laryngeal carcinoma using meta-analysis. Methods The case-control studies published in China about the expression and association of clinical pathogenic features of Survivin in the tissues of laryngeal carcinoma were electronically retrieved in CBM （1994 to October 2012）, CNKI （1994 to October 2012）, VIP （1989 to October 2012） and WanFang Data （1996 to October 2012）. The reviewers independently identified the literature according to inclusion and exclusion criteria, extracted data, and assessed the quality of the included studies. Then, meta-analysis was performed using RevMan 5.1 software. Results A total of 25 studies were included, involving 1 333 cases of laryngeal carcinoma and 528 cases of health laryngeal mucosa or polyp of vocal cord. The results of meta-analysis showed that, significant differences were found in groups of laryngeal carcinoma vs. health control, laryngeal carcinoma with vs. without lymphatic metastasis, clinical stages I-II vs. III-IV, cell differentiation G1 vs. G2-G3, T1 and T2 stages vs. T3 and T4 stages, and glottic carcinoma vs. non-glottic carcinoma （P〈0.05）. No significant difference was found in groups of age more than 60 vs. no less than 60, male vs. female, and smoke vs. non-smoke （P〉0.05）. Conclusion Current domestic evidence shows that Survivin may be associated with the whole course of occurrence, advance and transfer of laryngeal carcinoma, and positively correlated to degree of tumor malignance, which may indicate poor prognosis.

关 键 词：SURVIVIN 喉癌 系统评价 META分析 病例-对照研究 

分 类 号：R739.65[医药卫生—肿瘤]