和爽在肠道清洁中出现不良反应的因素分析  

Factor analysis of adverse reaction of compound polyethylene glycol-electrolyte powder in intestinal cleaning

作　　者：甘静娣[1] 周靖[1] 陈秀梅[1] 曾柳苑[1] 陈春梅[1] 

机构地区：[1]广州医科大学附属第二医院,广东广州511300

出　　处：《现代医药卫生》2013年第17期2573-2574,2576,共3页Journal of Modern Medicine & Health

摘　　要：目的 研究口服复方聚乙二醇电解质散（和爽）的不良反应与影响因素,并实施相应护理干预.方法 收集该院消化内科住院患者596例,对年龄、性别、服药水温以及胃病情况不同患者在口服和爽时的不同反应发生情况进行分析.结果 596例受试者中197例出现不同程度的不良反应,发生率为33.1%;同一受试者可出现多项不良反应,共计253例次,其中以腹胀最常见,占70.8%（179/253）.口服药物的水温在37 ℃以下的不良反应发生率为46.2%（127/275）,显著高于水温在37～40 ℃的发生率（21.8%,70/321）,差异有统计学意义（P〈0.05）;有胃部疾病的患者口服和爽过程中不良反应发生率为34.0%（103/303）,高于无胃部疾病的患者（32.1%,94/293）,差异有统计学意义（P〈0.05）.结论 引起口服和爽不良反应的影响因素主要为服药的水温和患者是否有胃部疾病.服药水温应保持在37～40 ℃,针对患者既往的胃病史应及早干预,能降低与预防不良反应的发生率.Objective To study the influencing factors and adverse effect of oral compound polyethylene glycol-electrolyte powder （Heshuang）, and to implement the corresponding nursing intervention. Methods A total of 596 patients in department of gastroenterology were selected. Reactions of different patients after oral administration of Heshuang on age, gender,water tem- perature and gastropathy were analyzed. Results Different degree of adverse reactions appeared in 197 cases from 596 patients with the incidence rate of 33.1%;the same patients might have many adverse reactions with a total of 253 patients and abdominal distension was the most common adverse reaction, accounting for 70.8% （ 179/253 ）. The incidence rate of adverse reaction when the medicinal water below 37 ℃was 46.2% （127/275）,which was obviously higher than that of the medicinal water temperature between 37-40 ℃ （21.8%, 70/321 ）, and the difference had statistical significance （P〈0.05）. The incidence rate of adverse reaction of the patients with gastric disease during the oral administration of cathartic was 34.0% （103/303） ,which was higher than that of the patients without stomach trouble （32.1%, 94/293 ）, and the difference had statistical significance （P〈0.05）. Conclusion The main influencing factors of adverse reaction by oral administration of Heshuang are medicinal water temperature and gastric disease. Keeping the medicinal water temperature between 37-40 ℃ and early intervention according to the patients＇ history of gastric disease can reduce or prevent the incidence rate of adverse reaction.

关 键 词：聚乙烯二醇类 副作用 电解质 投药 口服 肠道清洁 

分 类 号：R574.62[医药卫生—消化系统]