脑出血的遗传因素  

Genetic factors of intracerebral hemorrhage

作　　者：魏二佳[1,2] 杨立业[1] 

机构地区：[1]潮州市中心医院神经外科,广东潮州521021 [2]汕头大学医学院,广东汕头515041

出　　处：《分子诊断与治疗杂志》2013年第5期333-338,共6页Journal of Molecular Diagnostics and Therapy

基　　金：广东省社会发展计划(2012B031800001)

摘　　要：脑卒中是人类三大死因之一,具有发病率高、致残率高、死亡率高等特点。脑卒中分为出血性脑卒中和梗塞性脑卒中,出血性脑卒中又称脑出血,其死亡率及致残率更高。脑出血具有一定的家族遗传倾向,许多研究表明其与高血压、高脂血症、代谢综合征、凝血功能异常、动脉炎症等疾病有相关性。本文综述了近年来这些基础疾病研究中所发现与脑出血有关的遗传基因的研究进展。Brain stroke is one of three leading causes of human death,which has high incidence,high morbidity and high mortality.Brain stroke includes hemorrhagic stroke and ischaemic stroke.In particular,hemorrhagic stroke,also known as intracerebral hemorrhage（ICH）,has higher morbidity and mortality.ICH has some familial hereditary tendency.Nowadays,many studies suggest that several pathways have an effect on ICH,including hypertension,hyperlipidemia,metabolic syndrome,coagulation disorders and arterial infammation.This article presents a review of the recent literature on the genetics of ICH.

关 键 词：脑出血 遗传因素 基因多态性 

分 类 号：R743.34[医药卫生—神经病学与精神病学]