三有机锡苯甲酰甘氨酸酯的合成、结构表征和抑菌性质  

Synthesis,Structural Characterization and Anti-biological Activity of Triorganotin Benzoylglycinate

作　　者：韩鲁[1] 丁文超[1] 于游[1] 田来进[1] 

机构地区：[1]曲阜师范大学化学与化工学院,山东省曲阜市273165

出　　处：《曲阜师范大学学报（自然科学版）》2013年第4期63-68,共6页Journal of Qufu Normal University(Natural Science)

基　　金：国家自然科学基金(20701027);山东省自然科学基金(ZR2010BL012)

摘　　要：微波辐射下利用三有机基氯化锡、苯甲酰甘氨酸和甲醇钠在甲醇中反应,高产率地合成了三有机锡苯甲酰甘氨酸酯,C6H5CONHCH2CO2SnRR’2[R,R’=Ph,Ph(1);PhC(CH3)2CH2,PhC(CH3)2CH2(2);CH3OCOCH2CH2,Ph(3)],通过元素分析、IR、1 HNMR和X-射线单晶衍射分析确定了其结构.化合物2属单斜晶系,P21/c空间群,a=1.9476(2),b=1.9641(2),c=3.9198(4)nm,β=102.531(2)°,Z=16,V=14.637(3)nm3,R1=0.0517,wR2=0.1199.该化合物的锡原子具有4配位[SnC3O]畸变四面体构型,分子间通过配体中酰胺间的N-H…O氢键形成了一维链状超分子结构.化合物对大肠杆菌均有较强的抑制作用,其中1的活性最高,与氨苄西林钠相近.Triorganotin benzoylglycinates, C6 H5 CONHCH2 CO2 SnRR ＇ 2 [ R, R ＇ = Ph, Ph （ 1 ） ; PhC （CH3）zCHz ,PhC（CH3 ）zCHz （2） ;CH30COCHzCH2 ,Ph （3）] ,have been synthesized by the reaction of tri- organotin chloride,benzoylglycine and sodium methoxide in methanol solvent in good yield and character- ized by means of elemental analysis,IR,1 H NMR and X-ray single crystal diffraction. The crystal for 2 be- longs to monoclinic space group P21/c witha=1.9476（2）,b=1.9641（2）,c=3.9198（4） nm,β=102.531 （2）°,Z=16,V=14.637（3） nm3 ,R1 =O.0517,wRz=O.1199. The tin atom in 2 is four-coordinated and pos- sesses a distorted [SnC30] tetrahedral geometry and a one-dimension chain supramolecular structure is formed by the intermolecular N-H-O hydrogen bond among amido groups of ligands. These compounds have good anti-bacterial activity against E. coli,in which the activity of 1 is highest and similar to that of ampicillin sodium.

关 键 词：有机锡羧酸酯 苯甲酰甘氨酸 晶体结构 抑菌活性 

分 类 号：O614.432[理学—无机化学]