小细胞肺癌肿瘤组织VEGF表达及其与预后的关系  

Expression of VEGF and Its Correlation with Prognosis of Small Cell Lung Cancer

作　　者：卢红阳[1] 张谷[1] 蔡菊芬[1] 陈波[1] 王晓稼[1] 叶魏武[1] 雷蕾[1] 楼彩金[1] 覃晶[1] 毛伟敏[1] 

机构地区：[1]浙江省肿瘤医院,浙江省胸部肿瘤(肺,食管)诊治技术研究重点实验室,浙江杭州310022

出　　处：《肿瘤学杂志》2013年第10期768-771,共4页Journal of Chinese Oncology

基　　金：国家自然科学基金(81202806);浙江省医药卫生一般研究计划(2012KYB034);浙江省医药卫生平台骨干人才计划(2012RCB004)

摘　　要：[目的]探讨小细胞肺癌（SCLC）肿瘤组织中血管内皮生长因子（VEGF）的表达水平及其与预后的相关性。[方法]收集1998~2010年行手术治疗的35例SCLC患者,采用免疫组化法检测肿瘤组织中VEGF蛋白的表达水平,并分析其与预后的相关性。[结果]全组患者VEGF阳性表达率为45.7%,且均为弱阳性表达;在成功随访的22例患者中VEGF阳性表达与不表达患者的中位生存期差异无统计学意义（13个月vs 20个月,P=0.784）。[结论]近半数SCLC患者肿瘤组织中存在VEGF弱表达,VEGF表达与预后无明显相关性,抗血管生成的治疗策略在SCLC中有待进一步研究。[Purpose] To investigate the expression of vascular endothelial growth factor（VEGF）and its correlation with prognosis of small cell lung cancer（SCLC）.[Methods] Immunohistochemistry technology was used to detect the expression of VEGF protein in 35 cases with SCLC who received surgical treatment from 1998 to 2010,and its correlation with prognosis of SCLC was evaluated. [Results] VEGF expression rate was 45.7% in all SCLC patients and all samples were mild expression.There was no difference in median survival time（MST） between positive and negative VEGF expressions（13 months vs 20 months,P=0.784） in 22 followed-up cases.[Conclusion] Νear half SCLC patients show VEGF mild expression.VEGF expression does not correlate with prognosis. The strategy of antiangiogenesis in SCLC needs to be further studied.

关 键 词：癌 小细胞肺 血管内皮生长因子 预后 

分 类 号：R734.2[医药卫生—肿瘤]