As_2O_3联合Aspirin对615小鼠移植性前胃癌淋巴道转移的影响  

The Effect of As_2O_3 Combined with Aspirin on Infiltration and Lymphatic Metastasis of MFC in 615 Inbreeding Mice

作　　者：于丽丽[1] 李琳琳[2] 柳红[3] 

机构地区：[1]浙江省人民医院,浙江杭州310014 [2]徐州医学院第一附属医院,江苏徐州221002 [3]徐州医学院,江苏徐州221002

出　　处：《肿瘤学杂志》2013年第10期776-782,共7页Journal of Chinese Oncology

摘　　要：[目的]观察As2O3和Aspirin联合应用对615小鼠前胃癌侵袭、淋巴管生成及淋巴道转移的影响。[方法]建立小鼠前胃癌淋巴道移植瘤模型,用As2O3、Aspirin单独及联合作用后,测量各组小鼠体重、瘤重,计算肿瘤抑制率并计数瘤组织微淋巴管密度(LMVD)。[结果]与NS组相比,各治疗组615小鼠移植瘤生长均受抑制,Aspirin组抑瘤率为15.4%,As2O3组抑瘤率为43.8%,减半联合组为45.6%,联合组为60.4%,差异有统计学意义(P<0.05)。淋巴结内瘤组织转移抑制率As2O3组为22.4%,减半联合组和联合组分别为28.6%和50.0%。联合治疗组与减半联合组、Aspirin组、As2O3组及NS组相比,LMVD计数均显著减少,差异有统计学意义(P<0.05)。[结论]As2O3与Aspirin联合应用可抑制小鼠前胃癌移植瘤的生长、侵袭和淋巴道转移。[Purpose] To investigate the effect of As2O3in combination with Aspirin on the infiltration and lymphatic metastasis of highly metastasic mouse forestomach squamous carcinoma（MFC） in 615 inbreeding mice. [Methods] We set up 615 high-metastatic models of mouse tumor,giving different concentrations of As2O3and Aspirin. The body weight,tumour weight were measured and the tumor inhibition rate was calculated,and the microlymphatic vessel density（LMVD） was counted. [Results] The weight of tumors in 615-strain mice treated with As2O3combined aspirin was significantly lower than that of the others groups（P0.05）. The inhibition rate of tumor weight was 15.4% in Aspirin group,43.8% in As2O3group,45.6% in the half-dose combination group,60.4% in combination group. The tumor metastasis inhibition rate in lymph node,As2O3group was 22.4%,half-dose combination group was 28.6%,and combination group was 50.0%. LMVD in tumor tissues treated with drugs were evidently lower than that in the saline group（P0.05）,especially the combination group. [Conclusion] As2O3in combination with Aspirin could inhibit the growth,invasion and lymphatic metastasis of tumor tissue in 615-strain mice.

关 键 词：AS2O3 ASPIRIN 胃肿瘤 淋巴道转移 

分 类 号：R735.2[医药卫生—肿瘤]