父母生育年龄及围生期因素与孤独症的关系  

Association of autism with parents' childbearing age and perinatal factors

作　　者：刘文文[1] 杨曹骅[1] 张林娜 李梦瑶[1] 姜凌霄 李焱 江文庆[1] 赵志民[1] 李彩霞[1] 郝楠 郝丽丽 杜亚松[1] 

机构地区：[1]上海交通大学医学院附属精神卫生中心,200030

出　　处：《临床精神医学杂志》2013年第5期289-291,共3页Journal of Clinical Psychiatry

基　　金：国家重点基础研究发展计划(973);上海市科委项目:儿童孤独症早期识别;诊断及治疗的规范化方案研究(11411952401);上海市公共卫生体系建设三年行动计划(2011~2013)儿童孤独症(GWⅢ-32)

摘　　要：目的:探讨父母生育年龄及围生期因素对孤独症发病的影响。方法:对符合美国精神障碍诊断与统计手册第4版(DSM-IV)诊断标准的371例孤独症患儿(孤独症组)及采用分层随机抽样法收集的上海市幼儿园及中小学747名学生(正常对照组)父母生育年龄、该儿童的围生期情况进行统计分析。结果:父亲生育年龄在孤独症组较正常对照组高(χ2=46.672,P=0.000),差异具有统计学意义;孤独症组剖宫产率(χ2=15.480,P=0.000)、新生儿黄疸(χ2=17.395,P=0.000)发生率高于正常对照组,差异具有统计学意义。结论:父亲生育年龄较高可能子女罹患孤独症的风险高;剖宫产、新生儿黄疸可能是孤独症发病的危险性因素。Objective：To explore the association of autism with parents childbearing age and the perina- tal factors. Method：There were 371 children with autism （autism group） diagnosed by American diagnostic and statistical Manual for mental disorders 4thed （DSM-IV） and 747 kindgardnens and pupils of Shanghai＇s pri- mary and middle schools （normal control group） collected by a stratified random sampling method involved in this study. The childbearing age of parents and the condition of perinatal children were recorded and analyzed. Results：The childbearing age of father in autism group was significantly higher than normal control group （ x2 = 46. 672, P = 0. 000）. In autism group, the rate of cesarean section （ X2 = 15. 480, P = 0.000） and the inci- dence of neonatal jaundice （ X2 = 17. 395, P = 0. 000） were significantly higher than those in normal control group. Conclusion ：The higher childbearing age of father may be the risk factor of children with autism. The cesarean section and neonatal jaundice may be the risk factors of autism.

关 键 词：孤独症 父母亲生育年龄 剖宫产 新生儿黄疸 

分 类 号：R749.94[医药卫生—神经病学与精神病学]