RhoGDI2在胃癌中的原位表达及与临床病理特征的相关性  

Clinicopathological significance of expression of RhoGDI2 in gastric carcinoma

作　　者：石干[1,2] 田德安[1] 何星星[1] 廖家智[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院肝病研究所,湖北省武汉市430030 [2]武汉市中心医院消化内科,湖北省武汉市430014

出　　处：《世界华人消化杂志》2013年第27期2832-2837,共6页World Chinese Journal of Digestology

基　　金：国家青年自然科学基金资助项目;No.81101824~~

摘　　要：目的:检测RhoGTP酶解离抑制蛋白2(RhoGTPase dissociation inhibitor 2,RHOGDI2)在胃癌患者中的表达状况,并评价其与胃癌临床病理特征的相关性,评估RhoGDI2在胃癌侵袭转移中的临床意义.方法:采用免疫组织化学技术检测103例胃癌标本中RhoGDI2的表达.结果:RhoGDI2阳性表达细胞为肿瘤细胞,主要位于胞浆或胞核.RhoGDI2在胃癌组织表达率为72.82%(75/103),在非癌胃组织(病理结果示"黏膜呈轻度慢性炎症改变"或"正常胃黏膜表现")中无表达(0/21),差异有统计学意义(2=38.70,P<0.05);低分化型胃癌组显著高于高-中分化型胃癌组(2=6.37,P<0.05);随浸润深度(分别浸润至黏膜层、黏膜下层、肌层、浆膜层)增加,RhoGDI2的表达率增加(2=21.64,P<0.05);淋巴结转移组显著高于无转移组(2=54.50,P<0.05);远处转移组显著高于无转移组(2=19.81,P<0.05);临床分期Ⅲ+Ⅳ期组明显高于Ⅰ+Ⅱ期组(2=24.90,P<0.05).RhoGDI2表达与性别、年龄(<60岁或≥60岁)、肿瘤部位(贲门胃底、胃体、胃角、胃窦)、原发灶大小(直径<5 cm或≥5 cm)无相关性(P>0.05).结论:在胃癌组织RhoGDI2的表达与胃癌侵袭转移病理特征密切相关.RhoGDI2可能参与调节胃癌的侵袭转移的过程.AIM： To detect the expression of RhoGTPase dis- sociation inhibitor 2 （RhoGDI2） in gastric cancer, and to assess its correlation with clinicopatho- logical characteristic of gastric cancer. METHODS： Immunohistochemistry was used to detect the expression of RhoGDI2 in 103 gastric cancer specimens. RESULTS： RhoGDI2 was expressed mainly in the cytoplasm or the nucleus. The positive rate of RhoGDI2 protein expression was significantly higher in gastric cancer than in normal gastric tissue （72.82% vs 0.00%, Z2 = 38.70, P 〈 0.05）. The expression of RhoGDI2 protein was significantly correlated with tumor differentiation, invasion, lymph node metastasis, distant metastasis and stage （x2= 6.37, 21.64, 54.50, 19.81, 24.90, all P 〈 0.05）, but not with gender, age, tumor location or size. CONCLUSION： The expression of RhoGDI2 is closely related to the invasion and metastasis of gastric cancer.

关 键 词：胃癌 RhoGDI2 免疫组织化学 临床病理特征 

分 类 号：R735.2[医药卫生—肿瘤]