胰腺癌中KGF的表达及其临床病理学意义  

Clinicopathological significance of expression of keratinocyte growth factor protein in pancreatic ductal adenocarcinoma

作　　者：金益峰[1] 周建平[1] 盛伟伟[1] 张丹华[1] 董明[1] 

机构地区：[1]中国医科大学附属第一医院普通外科,辽宁省沈阳市110001

出　　处：《世界华人消化杂志》2013年第27期2865-2869,共5页World Chinese Journal of Digestology

基　　金：辽宁省自然科学基金资助项目;No.20092131~~

摘　　要：目的:探讨胰腺导管腺癌(pancreatic ductal adenocarcinoma,PDAC)中角质细胞生长因子(keratinocyte growth factor,KGF)的表达水平及临床病理学意义.方法:应用免疫组织化学方法检测51例胰腺癌及癌旁组织标本中KGF蛋白的表达水平,并且观察其表达与胰腺癌患者临床病理学资料的关系.结果:免疫组织化学结果显示:KGF在癌组织中表达明显高于配对的癌旁组织(Z=-4.766,P<0.001);KGF蛋白的表达与肿瘤肝转移呈正相关(2=4.113,P<0.05);生存分析发现KGF阳性患者的平均生存时间短于表达阴性者(阳性者平均生存时间384 d,阴性者621 d).结论:在PDAC中KGF表达上调,其表达与肿瘤肝转移呈正相关.KGF表达阳性患者生存时间短于阴性患者.AIM： To assess the clinicopathological signifi- cance of expression of keratinocyte growth fac- tor （KGF） protein in pancreatic ductal adenocar- cinorna （PDAC）. METHODS： The expression of KGF protein in 51 paraffin-embedded PDAC specimens and matched tumor-adjacent pancreatic tissue speci- mens was detected by irnmunohistochernistry. The relationship between KGF protein expres- sion and clinicopathological characteristics of PDAC was analyzed.RESULTS： The expression of KGF protein was significantly higher in PDAC than in matched pancreatic tissues （Z = -4.766, P 〈 0.001）. The expression of KGF protein was posi- tively correlated with hepatic metastasis （Z2 = 4.113, P 〈 0.05）. Mean survival time was shorter in KGF （＋） patients than in KGF （-） ones （384 d vs 621 d）. CONCLUSION： Expression of KGF is up-regulated in PDAC. KGF up-regulation may be related with hepatic metastasis of PDAC. Mean survival time is shorter in KGF （＋） patients than in KGF （-） ones.

关 键 词：肿瘤 胰腺癌 角质细胞生长因子 转移 

分 类 号：R735.9[医药卫生—肿瘤]