趋化因子配体18在乳腺癌组织中的表达及意义  

Expression and significance of CCL18 in breast cancer

作　　者：张晓申[1] 高进[1] 郑文博[1] 叶熹罡[1] 唐炜[1] 陈伦[1] 潘凌霄[1] 李君[2] 

机构地区：[1]广州医学院第一附属医院乳腺外科,广东广州510120 [2]广州医学院第一附属医院肝胆外科,广东广州510120

出　　处：《海南医学》2013年第19期2815-2817,共3页Hainan Medical Journal

摘　　要：目的探讨趋化因子配体18(CCL18)在乳腺癌组织中的表达及意义。方法选取我院乳腺外科2009年12月至2012年6月经病理确诊为乳腺癌患者组织标本80例,良性乳腺病患者组织标本40例,另取良性乳腺病患者病灶周边的正常乳腺组织20例作为对照组,全部入组病例为女性。采用免疫组化Envision方法,对标本检测CCL18的表达,并分析CCL18及Ki67在乳腺癌组的表达情况。结果 CCL18在对照组、良性乳腺病组均无表达,在乳腺癌组阳性率为71.25%(57/80);CCL18在乳腺癌组的表达与肿瘤的大小、病理分期、淋巴结转移个数呈正相关。CCL18在乳腺癌组织的表达与Ki67无相关性(P=0.091)。结论 CCL18可作为乳腺癌的生物学指标,与乳腺癌的浸润性及转移有一定的关系,但与肿瘤细胞的增殖无关,对认识乳腺癌的生物学特性以及判断预后有重要意义。[Abstract] Objective To investigate the expression and significance of Chemokine CC-motif ligand 18 （CCL18） in breast cancer. Methods Eighty tissue samples from patients with breast cancer （breast cancer group）, 40 tissue samples from patients with benign breast diseases （benign breast diseases）, and 20 healthy tissue samples aside the benign lesions from the patients with benign breast disease （the control group） were collected in the Department of Breast Surgery of our hospital from December 2009 to June 2012. Envision immunohistochemical method was used to examine the expression of CCL 18, and SP immunohistochemical method was applied to examine the expression of Ki67. The correlation between the expression of CCLI8 and Ki67 in breast cancer was analyzed. All the patients col- lected were female. Results There was no CCL18 expressed in the control group and the benign breast diseases group, but 57 cases in the breast cancer group showed positive results, with the positive rate of 71.25%. Obviously, the expression level of CCL18 in the breast cancer group was significantly higher than the other two groups （P〈0.001）, and it increased with higher tumor burden defined by tumor size （P=0.035）, staging （P〈0.001）, and lymphovascular in- vasion （P〈0.001）. No significant correlation was found between the expression level of CCL18 and Ki67 （P--0.091）. Conclusion CCLI 8 is the marker of breast cancer. High expression of CCL18 in breast cancer has a relationship with tumor invasion and metastasis, but is unrelated to the proliferation of cancer cells. CCL18 is of great importance for studying the bionomics of breast cancer and evaluating the prognosis of breast cancer.

关 键 词：乳腺癌 趋化因子配体18(CCL18) KI67 

分 类 号：R737.9[医药卫生—肿瘤]