热疗联合同步放化疗治疗中晚期宫颈癌的临床观察  

Clinical study of hyperthermia combined with radiochemotherapy for the treatment of advanced cervical cancers

作　　者：杜珂[1] 靳义强[1] 李泉[1] 

机构地区：[1]襄阳市中心医院肿瘤科,湖北襄阳441021

出　　处：《海南医学》2013年第19期2837-2839,共3页Hainan Medical Journal

摘　　要：目的观察热疗(Hyperthermia,HT)联合同步放化疗在中晚期宫颈癌治疗中的临床疗效及毒副反应。方法将2007-2011年我院收治的78例中晚期宫颈癌患者随机分为对照组和试验组,每组各39例。对照组采用三维适形放疗及后装放疗同步顺铂化疗(40 mg/m2,每周一次,共6次),试验组在对照组基础上加用热疗(每次60 min,2次/周,共12次),观察两种治疗方法近期疗效和毒副反应。结果试验组近期有效率为92.3%,对照组为74.4%,两组比较差异有统计学意义(χ2=4.52,P<0.05)。治疗组副反应稍高于对照组,但差异无统计学意义(P>0.05)。结论热疗联合同步放化疗治疗宫颈癌近期疗效较好,毒副反应轻,值得推广。Objective To evaluate the clinical efficacy and side effects of hyperthermia combined with radio- chemotherapy in the treatment of advanced cervical caneer. Method Seventy-eight patients with advanced cervical cancer who admitted in our hospital from 2007 to 2011 were randomly divided into the experimental group and the control group, each with 39 cases. The control group applied three dimensional conformal radiation therapy （3DCRT） and intracavitary brachytherapy combined with cisplatin at the dose of 40 mg/mz once a week for 6 times. The experi- mental group was combined with hyperthermia lasting for 60 min twice weekly, 12 times totally. The clinical efficacy and side effects were evaluated in both groups. Results The effective rate was 92.3% in the experimental group and 74.4% in the control group, with statistically significant difference （Z^--4.52, P〈0.05）. The incidence of side effects in the experimental group was slightly higher than that in the control group, with no statistically significant differemce between the two groups （P〉0.05）. Conclusion Hyperthermia combined with radiochemotherapy has a better short-term efficacy in the treatment of advanced cervical cancer, with slight side effects.

关 键 词：子宫颈癌 放化疗 热疗 疗效 

分 类 号：R737.33[医药卫生—肿瘤]