溃疡性结肠炎相关性结直肠癌中AOM/DSS模型应用研究  

Advances on the application of AOM/DSS model in ulcerative colitis associated colorectal cancer

作　　者：吴琼[1,2] 郭蒙[1,2] 叶华[2] 朱宇珍[2] 郑学宝[2] 

机构地区：[1]广东医学院药理教研室,广东湛江524023 [2]广东医学院广东天然药物研究与开发重点实验室,广东湛江524023

出　　处：《海南医学》2013年第19期2880-2883,共4页Hainan Medical Journal

基　　金：国家自然科学基金(编号:30772701);广东省科技计划项目(编号:2011B03170065);广东省建设中医药强省项目(编号20112144);湛江市科技攻关项目(编号:2009C3104003)

摘　　要：在化学诱导结肠炎相关性结肠癌模型中,氧化偶氮甲烷(Azoxymethane,AOM)/葡聚糖硫酸钠(Dextran sodium sulfate,DSS)可以大大缩短结肠炎诱导癌变的时间,重现人类结直肠癌隐窝病灶-腺瘤-腺癌发展顺序。由于AOM/DSS模型重现率高,以及简单的造模方法,已成为化学预防研究的典型造模方法。本文从AOM/DSS动物模型、炎症相关性癌症及结直肠癌中AOM/DSS模型的应用、结直肠癌组织学三个方面对炎症相关性结直肠癌作一综述。Among the chemically induced CRC models, the combination of a single hit of azoxymethane （AOM） to the inflammatory agent dextran sodium sulpate （DSS） in rodents has proven to dramatically shorten the la- tency time for induction of CRC and to rapidly recapitulate the aberrant crypt ofci-adenoma-careinoma sequence that occurs in human CRC. Because of its high reproducibility and potency, as well as the simple and affordable mode of application, the AOM/DSS has become an outstanding model for studying colon carcinogenesis and apowerful plat- form for chemopeventice intervention studies. This review briefly summarizes the current advances in the AOM/DSS model, inflammation and tumorigenesis in the AOM/DSS, as well as histogenesis of CRC in the AOM/DSS model.

关 键 词：溃疡性结肠炎相关性结直肠癌 结直肠癌 动物模型 AOM DSS 

分 类 号：R735.37[医药卫生—肿瘤]