不同类型的胃炎和胃癌组织中p21、p16蛋白的表达及临床意义  

Expression of p21 and p16 proteins in different gastritis and gastric cancer tissues and the clinical significance

作　　者：李蓉[1] 赵梦云[1] 张永红[1] 李荣 

机构地区：[1]西安市第一医院消化科,陕西西安710002 [2]西安市第五医院内三科,陕西西安710082

出　　处：《海南医学》2013年第20期2968-2969,共2页Hainan Medical Journal

基　　金：陕西省卫生厅科学研究基金项目(编号:08H16)

摘　　要：目的探讨不同类型胃炎与胃癌的相关性。方法采用免疫组化法检测p21、p16在疣状胃炎、非萎缩性胃炎、萎缩性胃炎及胃癌各40例组织中的表达,并对各组值进行比较,得出结论。结果 p21在非萎缩性胃炎、萎缩性胃炎、疣状胃炎及胃癌组织的表达分别为0、22.5%、35.0%、60.0%,疣状胃炎的p21阳性率显著高于非萎缩性胃炎,低于胃癌,各组间比较差异有统计学意义(P<0.05),但与萎缩性胃炎比较差异无统计学意义;p16在非萎缩性胃炎、萎缩性胃炎、疣状胃炎及胃癌组织的表达分别为90.0%、50.0%、45.0%、17.5%,疣状胃炎组p16阳性率显著低于非萎缩性胃炎,明显高于胃癌组,各组间比较差异有统计学意义(P<0.01),但与萎缩性胃炎比较差异无统计学意义。结论 Ras基因激活后形成的p21蛋白及抑癌基因p16失活可能参与疣状胃炎的癌变过程。Objective To explore the relationship between different types of gastritis and gastric cancer. Methods The expression of p21 and p16 proteins in varioliform gastritis, non-atrophic gastritis, atrophic gastritis, and gastric cancer was detected by immunohistochemistry. The results were compared. Results The positive rate of p21 protein expression in non-atrophic gastritis, atrophic gastritis, varioliform gastritis, gastric cancer was 0, 22.5%, 35.0%, 60.0%, respectively, which was significantly higher in varioliform gastritis than non-atrophic gastritis, but sig- nificantly lower than gastric cancer （P〈0.05）. The positive rate ofpl6 protein expression in non-atrophic gastritis, atro- phic gastritis, varioliform gastritis, gastric cancer was 90.0%, 50.0%, 45.0%, 17.5%, respectively, which was signifi- cantly lower in varioliform gastritis than non-atrophic gastritis, but significantly higher than gastric cancer （P〈0.01）. No significant differences were noted between varioliform gastritis and atrophic gastritis. Conclusion Both p21 and pl6 proteins may be involved in the evolution of varioliform gastritis to gastric cancer.

关 键 词：疣状胃炎 胃癌 P21蛋白 P16蛋白 

分 类 号：R573.3[医药卫生—消化系统]