中药复方逆转肿瘤多药耐药研究近况及相关PI3K/AKT/NF_(-κ)B分子通路分析  

Traditional Chinese medicine compound in reversal of multidrug resistance in tumors and the analysis on PI3K/AKT/NF_(-κ)B molecular pathway

作　　者：刘永衡[1,2] 郎娜[3] 陈秀[1] 

机构地区：[1]中国人民解放军第二炮兵总医院心胸外科,北京100088 [2]中国人民解放军总参总医院肿瘤科 [3]中国中医科学院西苑医院皮肤科

出　　处：《环球中医药》2013年第9期704-708,共5页Global Traditional Chinese Medicine

基　　金：中国博士后科学基金(2012M521903)

摘　　要：肿瘤的多药耐药(MDR)是导致化疗失败的重要原因之一。目前中医药逆转MDR的研究大多集中在单一药物或单一提纯成分方面,而关于中药复方逆转MDR的研究较少。本文对近年来中药复方逆转MDR的相关研究作一总结,发现研究者分别从抑制P-糖蛋白(P-gp)的酶活性、降低多耐药基因1信使核糖核酸(MDR1mRNA)表达、诱导肿瘤细胞凋亡、下调B细胞淋巴瘤-2(Bcl-2)的表达等方面解释了其的作用机制。但是多数研究仅限于一个或两个靶点蛋白,未能提出具体的分子通路。笔者结合自身研究基础,分析MDR形成机制中一条比较重要的磷脂酰肌醇3-激酶/A蛋白激酶/核因子-κB(PI3K/AKT/NF-κB)分子通路,并借此探讨中药复方逆转肿瘤MDR研究的新思路。The multi drug resistance （MDR） in tumors is the most common cause of chemotherapy failure. Most of the current researches on the traditional Chinese medicine in reversal of MDR still focus on a single drug or extracted content, and seldom shows interest in Traditional Chinese medicinal compounds. This paper makes a review on the study of the traditional Chinese medicine reversing MDR in recent years. It found that researchers explained the MDR mechanisms from following ways such as inhibition of the P-gp enzyme activity, decreasing the expression of MDRlmRNA, inducing tumor cell apoptosis,and lowering the expression of Bcl-2 Considering most researches＇ limitation to no more than 2 target proteins, and failure to put forward specific molecular pathways. The authors, based on our early researches, made analysis on an important molecular pathway-the PI3K/AKT/NF-κB pathway of MDR mechanism, in order to explore new ideas on the research of traditional Chinese medicine compound reversing the MDR of tumor.

关 键 词：中药 肿瘤 多药耐药 PI3K/AKT/NF-κB 分子通路 

分 类 号：R730.3[医药卫生—肿瘤]