大鼠舌癌变细胞分化异常的表型特征——角蛋白谱分析  

THE PHENOTYPIC CHARACTERISTICS OF SQUAMOUS CELL ABERRANT DIFERENTIATION IN RAT TONGUE CARCINOGENESIS: AN ANALYSIS OF CYTOKERATIN EXPRESSION PATTERN

作　　者：刘兴坤[1] 何荣根[1] 陈万涛[1] 周晓健[1] 周曾同[1] 

机构地区：[1]上海第二医科大学附属第九人民医院口腔颌面外科,200011

出　　处：《口腔颌面外科杂志》2000年第3期228-230,共3页Journal of Oral and Maxillofacial Surgery

基　　金：国家自然科学基金资助 !( NO.396 70 787)

摘　　要：目的　阐明口腔癌变细胞分化异常的表型特征。方法　 L SAB免疫组化方法检测 69例 4-硝基喹啉 -1-氧化物 ( 4 NQO)口服诱发大鼠舌癌变各期组织分化标志角蛋白 ( CK) 10 ,13 ,14的表达。结果　随口腔癌变进展 ,CK14自基底层向上逐渐延伸至基底上层表达 ;基底上层 CK13表达逐渐减少 ;基底上层 CK10表达在癌前逐渐上升 ,成癌后则聚然下降。结论　口腔癌变是一种细胞分化异常疾病 。Objective To clarify the characteristics of squamous cell aberrant differentiation in oral carcingogenesis. Method A total of 69 rat tongue carcinogensis specimens induced by 4 nitroquinoline 1 oxide (4NQO) were detected for cytokeratin (CK) 10,13,14 by LSAB immunohistochemical staining. Results With the progress of oral carcinogenesis, abnormal CK expression pattern was indicated by reduced expression of CK13, suprabasal expression of CK14, and increased CK10 expression in premalignant lesions while reduced in squamous cell carcinoma. Conclusion Oral carcinogenesis is the result of mucosa epithelium cell aberrant differentation. An abnormal CK expression pattern may be the main phenotypic characteristics of disdifferentiation in oral carcinogenesis.

关 键 词：口腔 癌变 分化 角蛋白 舌癌 病理 

分 类 号：R739.8[医药卫生—肿瘤]