吸烟与口腔鳞癌发病相关性的病例对照研究  

A CASE-CONTROL STUDY ON AN ASSOCIATION BETWEEN SMOKING AND ORAL SQUAMOUS CELL CARCINOMA

作　　者：张森林[1] 孟昭业[1] 张怀勤[1] 周楠[1] 

机构地区：[1]南京军区南京总医院口腔科,210002

出　　处：《口腔颌面外科杂志》2000年第3期231-233,共3页Journal of Oral and Maxillofacial Surgery

摘　　要：:目的　明确吸烟与口腔鳞癌发病之间的关系。方法　对病例组 74例口腔鳞癌患者和对照组 13 1例腮腺多形性腺瘤患者的吸烟史进行了调查分析 ,计算优势比 ( OR) ;为排除性别和年龄这两个可能的混杂因素的影响 ,同时对男性患者和 45岁以上患者吸烟史进行对比分析。结果　病例组有 43例吸烟 ,3 1不吸烟 ;对照组有 2 9例吸烟 ,10 2例不吸烟 ;OR为 4.9( P<0 .0 0 5 )。在男性患者和 45岁以上患者中 ,OR分别为 6.0和 5 .3 ( P<0 .0 0 5 )。Purpose To further examine a preliminary association between smoking and the subsequent development of oral squamous cell carcinoma. Method 74 Consecutive patients with oral squamous cell carcinoma served as cases and 131 consecutive patients with pleomorphic adenomas of the parotid gland as controls. A smoking history of every patient was obtained, and calculation of an odds ratio (OR) was carried out. In order to exclude sex and age as possible confounders, the odds ratio was recalculated. Results In the entire study population, there were 43 smokers and 31 nonsmokers in the cases and 29 smokers and 102 nonsmokers in the controls. An odds ratio of 4.9 was determined in favor of the association between smoking and oral squamous carcinoma ( P < 0.005). In males only, there were 35 smokers and 11 nonsmokers in the cases and 20 smokers and 38 nonsmokers in the controls, with an odds ratio of 6.0 ( P <0.005). In the patients over 45 years of age, there were 34 smokers and 15 nonsmokers in the cases and 17 smokers and 40 nonsmokers in the controls, with an odds ratio of 5.3( P <0.005). Conclusion Smoking may be one of the etiologic factors associated with oral squamous cell carcinoma.

关 键 词：口腔鳞癌 吸烟 鳞状细胞部 病例对照研究 

分 类 号：R739.8[医药卫生—肿瘤]