P53家族成员及相互作用与白血病关系的研究进展  

Advances of Studies on Members of P53 Family,Interaction and Relation with Leukemia——Review

作　　者：谢咪雪[1] 谢彦晖[1] 

机构地区：[1]复旦大学附属华东医院血液科,上海200040

出　　处：《中国实验血液学杂志》2013年第5期1331-1335,共5页Journal of Experimental Hematology

摘　　要：P53基因具有诱导细胞凋亡、调控细胞周期、修复DNA损伤等重要功能,超过50%人类肿瘤及13%的血液系统恶性肿瘤中均存在P53基因的突变,P53基因异常与白血病的临床病程、预后转归等密切相关。与此同时,与P53结构具有高度同源性的P53家族成员P73、P63基因不仅具有与P53相似的诱导细胞凋亡、转录激活等活性,又可根据转录蛋白结构的多样性发挥不同的生物学作用,甚至拮抗P53基因的功能。研究发现,P73、P63基因同时具有抑癌和癌基因的双重特性,且在不同类型、不同阶段白血病中两者表现出不同表达活性及功能。本文就P53家族(P53、P73、P63)基因的结构、生物学功能异同点以及三者与白血病病程、预后转归、治疗等临床特点的关系作一综述。The P53 gene has the important functions including induction of apoptosis, regulation of cell cycle, repair of DNA damage. The mutation of the P53 gene exists in more than 50% of human tumors and 13% of hematological malignancies. The P53 gene abnormality is closely related with the clinical course and prognosis of leukemia. The P73 or P63 gene, the member of the P53 family not only possesses similar to P53 activity of inducing apoptosis, activating transcription, but also plays different biological effects according to protein structural diversity, and even antagonises the function of the P53 gene. Researchers found that P73 or P63 gene also has the dual characteristics of the tumor suppres- sor and oncogene, and shows different expression and function in different types, different stages of leukemia. In this ar- ticle, P53 family （P53, P73, P63 ） gene structure, biological function and the relationship of the three genes with the course, prognostic outcome, treatment and other clinical features of the leukemia are reviewed.

关 键 词：白血病 P53家族 P53基因 P63基因 P73基因 

分 类 号：R733.7[医药卫生—肿瘤]