Oct4基因在消化系肿瘤中的研究进展  

Role of Oct4 in gastrointestinal tumors

作　　者：黎江[1] 文坤明[1] 曾庆良[1] 

机构地区：[1]遵义医学院附属医院胃肠外科,贵州省遵义市563000

出　　处：《世界华人消化杂志》2013年第28期2969-2974,共6页World Chinese Journal of Digestology

基　　金：贵州省科学技术基金资助项目;No.黔科合J字[2012]2365;国家自然科学基金资助项目;No.81260369~~

摘　　要：八聚体结合转录因子4(octamer-binding transcriptionfactor 4,Oct4)基因是POU转录因子家族中的一员,是维持干细胞多潜能性和自我更新的最重要转录因子之一.Oct4不仅在胚胎干细胞和生殖细胞及其肿瘤中有表达,且在多种体细胞恶性肿瘤中也均有表达现象,与恶性肿瘤患者的发生发展及临床预后存在密切的关系,对肿瘤的诊断及治疗有着深远的影响.本文就Oct4在消化系肿瘤中的作用及机制方面的研究给予综述.Octamer-binding transcription factor 4 （Oct4）, a member of the POU transcription factor family, is one of the most important transcription factors for maintaining pluripotent and self-renewing state of stem cells. Oct4 is expressed not only in embryonic stem cells, germ cells and germ cell tumors but also in a variety of somatic cells of malignant tumors. The expression of Oct4 is closely related to the development and progno- sis of malignant tumors. Therefore, detection of Oct4 expression has great significance in the diagnosis and treatment of tumors. This article provides a brief review of the role of Oct4 in gas- trointestinal tumors.

关 键 词：八聚体结合转录因子4 消化系肿瘤 诊断 治疗 预后 

分 类 号：R735[医药卫生—肿瘤]