中性粘多糖对脑缺血再灌注沙土鼠红细胞β-内啡肽和免疫粘附功能的影响  

The Study on the Effect of NM Upon RBC-β-EP and RCIA During Cerebral Ischemia_repe_rfusion in Gerbil

作　　者：丁素菊[1] 郑惠民[1] 侯晓军[1] 郭峰 王成海 

机构地区：[1]第二军医大学长海医院神经内科,上海市200433 [2]长海医院免疫生化室 [3]第二军医大学神经生物教研室

出　　处：《中国微循环》2000年第3期158-159,共2页Journal of Chinese Microcirculation

基　　金：上海市自然科学资金资助

摘　　要：观察中性粘多糖(neutralmucopolysaccharideNM)对缺血再灌注沙土鼠红细胞 β-内啡肽(β-endorphinβ-EP)和免疫粘附功能(redcellimmuneadherence,RCIA)的影响 ,进一步探讨NM对防治缺血再灌注脑组织损伤的机理。方法采用蒙古种沙土鼠缺血再灌注模型分别测定红细胞β-EP(RBC -β-EP)以及RCIA ,观察两者相互关系。结果提前喂服NM在沙土鼠缺血再灌注时RBC -β-EP含量明显降低 ,RCIA能力增强 ;随RBC -β-EP含量下降 ,RCIA功能有所加强。结论NM在沙土鼠脑缺血再灌注时具有阻断RBCObjective. To investigate the effect of NM upon RBC-β-EP anf RCIA during cerebral ischemia_reperfusion in gerbil and to probe into the protective effect of NM upon brain damage following cerebral ischemia and reperfusion.Methods RCIA and RBC-β-EP were both measured in models of cerebral ischmia and reperfusion of Mongolian gerbil. Results RBC-β-EP decreases markedly while RCIA strengthens during cerebral ischemia and reperfusion in gerbil pretreated with NM. Conclusions RBC-β-EP promoted the function of RCIA, excessive amounts of RBC-β-EP inhibited the function of RCIA. This suggests that NM can block RBC-β-EP production. It contributes to improve the function of RCIA in cerebral ischemia reperfusion.

关 键 词：Β-内啡肽 免疫粘附功能 脑缺血再灌注损伤 

分 类 号：R743.302[医药卫生—神经病学与精神病学]