食管癌合并脉管瘤栓患者的临床研究  

Clinical study of esophageal cancer in patients with vascular tumor thrombus

作　　者：侯向生[1] 王玉香[1] 

机构地区：[1]郑州大学第二附属医院胸外科,河南郑州450014

出　　处：《中国伤残医学》2013年第10期18-19,共2页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:探讨食管癌合并脉管瘤栓患者的临床病理特点、与P53、Ki67、表达和5年生存率的关系。方法:回顾性分析84例食管癌合并脉管瘤栓患者的临床病理资料、P53、Ki67表达和5年生存率。结果:食管癌合并脉管瘤栓患者的淋巴结转移数目越多脉管瘤栓发生率越高(P<0.01);瘤细胞分化程度低/未分化癌较高/中分化的脉管瘤栓有显著意义(P<0.01);食管癌合并脉管瘤栓与免疫组化P53、Ki67阳性与阴性比较有差异(P<0.05)。食管癌患者5年生存率在脉管瘤栓阳性与阴性表达患者之间比较有显著差异(P<0.05)。结论:食管癌合并脉管瘤栓的发生与食管癌患者的年龄、性别无关;与临床病理的淋巴结转移数目及P53、Ki67的阳性表达呈正相关关系,与细胞分化程度表达呈负相关关系,合并脉管瘤栓患者预后差。把脉管瘤栓加入现行的TNM分期中结合P53、Ki67联合检测可能更具有临床指导意义。Objective：To investigate the merger of esophageal cancer in patients with vascular invasion clinical and pathological fea- tures, and P53, Ki67, expression and 5 year survival. Methods： A retrospective analysis of 84 eases of esophageal cancer in patients with vascular invasion combined clinical and pathological data, P53, Ki67 expression and 5 - year survival rate. Results ： Esophageal cancer combined vascular invasion of lymph node metastasis in patients with the more higher the incidence of vascular invasion （ P 〈 0.01 ） ; poorly differentiated tumor cells / undifferentiated carcinoma, high / medium differentiation of vascular invasion was significant （ P 〈 0. 01 ） ; esophageal combined vascular invasion and immunohistochemical P53, Ki67 - positive compared with negative differences （ P 〈 0. 05 ）. 5 - year survival rate of patients with esophageal cancer tumor thrombus in the vascular expression of positive and negative patients there was a significant difference between （ P 〈 0.05 ）. CONCLUSION： Esophageal cancer incidence of vascular invasion combined with esophageal cancer patient~ age, sex; lymph node metastasis and clinical pathology number and P53, Ki67 positive expression was posi- tively correlated with the degree of cell differentiation expression was negatively correlated, the combined vascular tumor thrombus in pa- tients with poor prognosis. Pulse tube tumor thrombus into the existing TNM staging combined P53, Ki67 combined detection may be moreclinical significance.

关 键 词：食管癌 脉管瘤栓 P53 KI67 

分 类 号：R73[医药卫生—肿瘤]