脑干梗死患者肠黏膜屏障功能变化研究  

STUDY ON INTESTINAL MUCOSAL BARRIER IN PATIENTS WITH BRAIN STEM INFARCTION

作　　者：崔泽岩[1] 王惠凌[2] 王德超[2] 霍玉娥[2] 刘斌[3] 

机构地区：[1]河北省保定市第二医院老年病科,河北保定071000 [2]河北大学附属医院神经内科,河北保定071000 [3]河北省保定市第五医院烧伤科,河北保定071000

出　　处：《河北医科大学学报》2013年第10期1125-1127,共3页Journal of Hebei Medical University

摘　　要：目的探讨脑干梗死患者肠黏膜屏障变化。方法选取脑干梗死患者36例,于患病后24h、72h、1周、2周采集静脉血,同时选取健康体检者30例作为对照,抽取外周血,采用双抗体夹心ELISA法测定血清二胺氧化酶(diamine oxidase,DAO)、D乳酸(D-lactic acid,D-LAC)含量。结果脑干梗死在患病后很快出现肠黏膜屏障功能改变,在患病24h血浆D-LAC、DAO明显增高,在72h至1周达高峰,2周内无降低趋势。结论脑干梗死患者患病后24h内即可出现黏膜屏障功能损伤,并且损害可持续2周或更长时间。Objective To study the changes of intestinal mucosal barrier in patients with brain stem infarction.Methods Thirty-six patients with brain stem infarction,respectively in 24h,72h,1 week,2 weeks after the disease were enrolled,the venous blood sample was collected,and 30 healthy subjects served as controls.The serum diamine oxidase（DAO） and D-lactic acid （D-LAC） were detected in 27 patients with brain stem hemorrhage and 30 normal controls by double antibody enzyme linked immunosorbent assay.Results Intestinal mucosal barrier function showed changes in the patients with brain stem infarction soon after the disease.The plasma D-lactate,and DAO increased in 24h after the disease,reached the peak from 72h to 1 week,and maintained in 2 weeks.Conclusion Brain stem infarction patients can present mucous membrane barrier function damage after the disease in 24h and the damage can last 2 weeks or longer.

关 键 词：脑干梗塞 肠 黏膜 

分 类 号：R743.33[医药卫生—神经病学与精神病学]