首发未经治疗精神分裂症患者认知功能与血清脑源性神经营养因子的关系  

The relationship between cognition and brain-derived neurophic factor in patients with first-episode schizophrenia

作　　者：王宏[1] 温盛霖[2] 程敏锋[2] 岳计辉[1] 

机构地区：[1]中山大学附属第五医院精神心理科,广东珠海519000 [2]中山大学附属第三医院精神心理科

出　　处：《中国预防医学杂志》2013年第10期741-744,共4页Chinese Preventive Medicine

基　　金：2009年广东省自然科学基金资助项目(9151008901000027)

摘　　要：目的探讨精神分裂症认知损害特点及其与血清脑源性神经营养因子(BDNF)的关系。方法对34例首发未经治疗精神分裂症患者(患者组),33名健康者(对照组)采用数字符号编码及符号搜索测验、连线测验、色字词测验、韦氏记忆测验、威斯康辛卡片分类测验和酶联免疫吸附法进行认知功能评定和血清BDNF浓度的检测。结果 (1)各项测验中,除连线A错误数[(0.58±1.15)vs(0.15±0.71),t=1.85,P=0.068]、符号搜索错误数[(2.41±3.61)vs(1.48±1.95),t=1.31,P=0.19]指标之外,患者组的成绩均差于对照组。(2)患者组血清BDNF浓度低于对照组[(2.43±1.58)μg/Lvs(3.96±2.28)μg/L,t=-3.18,P=0.002]。(3)患者组认知缺陷与血清BDNF水平之间无相关性。结论精神分裂症患者存在广泛认知损害和BDNF降低;精神分裂症认知损害与血清BDNF关系不大。Objective To assess the relationship between cognition and brain derived neurotrophic factor （BD- NF） in patients with first-episode schizophrenia. Methods 34 patients with first-episode schizophrenia and 33 healthy controls were enrolled into the study. Their cognition ability was assessed by using a battery of neu- ropsychologieal test, which included Trail making test,, Stroop test, Symbol coding, Symbol search, Wis- consin card sorting test and Wechsler memory scale. Serum BDNF level was determined by ELISA. Results Compared with healthy controls, patients with first-episode schizophrenia had lower scores in all tests except the errors in the symbol search （（2.41±3.61） vs （1. 48±1.95）, t=1.31, P=0.19] and the errors in Trail making test A [ （0.58±1.15） vs （0.15±0.71）, t=1.85, P=0.068] .The serum BDNFlevel was lower in patients with first-episode schizophrenia than that in healthy controls [ （2.43±1.58） ug/L vs. （3.96±2.28） ug/L t=-3. 18, P=0. 002] . The impaired cognition of patients was not related to serum BDNF lev- el. Conclusions Although cognitive impairment and low BDNF level are noticed in patients with first-episode schizophrenia, the two are not closely related.

关 键 词：首发未经治疗精神分裂症 认知功能 血清脑源性神经营养因子 

分 类 号：R749.3[医药卫生—神经病学与精神病学]