六种高等真菌醇提物的抗肿瘤活性筛选  

Screening of Anti-tumor Activities of Ethanol Extracts from Six Species of Higher Fungi

作　　者：袁小红[1] 张春杰[1] 郑仁林[1] 徐健蓉[1] 刘卓[1] 陈粟源[1] 贺新生[1] 

机构地区：[1]西南科技大学生命科学与工程学院,四川绵阳621010

出　　处：《西南科技大学学报》2013年第3期95-97,共3页Journal of Southwest University of Science and Technology

基　　金：国家自然科学基金项目(21272189)

摘　　要：采用MTT法测试海绵胶煤炱菌、条纹炭角菌、瑞克纤孔菌、木蹄层孔菌、红缘拟层孔菌和高木蹄层孔菌6种高等真菌醇提物对人食道癌细胞(Eca109、TE-1)、人肺腺癌细胞(PC-9)、人结肠癌细胞(HT29,HCT116)、人乳腺癌细胞(MCF-7,MDA-MB-231)、人肝癌细胞(HepG2,SMMC-7721)和人白血病细胞(MV4-11,H1975)等11种恶性肿瘤细胞的抗肿瘤活性。结果表明:海绵胶煤炱菌醇提物对Eca109,MDA-MB-231,MV4-11和SMMC-7721四种瘤株有较强的抗肿瘤活性,条纹炭角菌醇提物对SMMC-7721瘤株有较强的抗肿瘤活性。Antitumor activities of the ethanol extracts of Scorias spongiosa, Xylaria grammica Pat. , [non- otus rickii, Fornes fomentarius, Fomitopsis pinicola and Fomes robustus against eleven kinds of malignant tumor cell line （Ecal09, TE-1, PC-9, HT29, HCT116, MCF-7, MDA-MB-231, HepG2, SMMC -7721, MV4 -11 and H1975） were tested by MTT assay. The results show that the ethanol ex- tract of Scorias spongiosa has strong antitumor activity against Ecal09, MDA -MB -231, MV4 -11 and SMMC -7721 cell, and the ethanol extract of Xylaria grammica Pat. has strong antitumor activity against SMMC - 7721 cell.

关 键 词：海绵胶煤炱菌 条纹炭角菌 抗肿瘤活性 MTT法 

分 类 号：Q949.32[生物学—植物学] R730.5[医药卫生—肿瘤]