血管内皮生长因子、白细胞分化抗原34及CXC趋化因子受体4在转移性鼻咽癌患者鼻咽部肿瘤组织的表达与预后分析  

Expression of VEGF,CD34 and CXCR4 and heir Prognostic Signiicance in Metastatic Nasopharyngeal Carcinoma

作　　者：罗馨玫[1] 姜愚[1] 邹立群[1] 冀晓辉[1] 邓国华[1] 汤捷[1] 

机构地区：[1]四川大学华西医院肿瘤中心/生物治疗国家重点实验室,成都610041

出　　处：《华西医学》2013年第9期1405-1410,共6页West China Medical Journal

基　　金：国家自然科学基金(81172202)~~

摘　　要：目的检测血管内皮生长因子(VEGF)、白细胞分化抗原34(CD34)及CXC趋化因子受体4(CXCR4)在转移性鼻咽癌患者鼻咽部肿瘤组织中的表达,探讨它们与鼻咽癌各种临床病理因素的关系以及它们之间的相互联系。方法采用免疫组织化学链霉素抗生物素蛋白-过氧化物酶连结法检测2003年3月-2009年5月35例转移性鼻咽癌患者VEGF、CD34及CXCR4在鼻咽部肿瘤组织中的表达情况,结合患者临床病理特征进行分析。结果转移性鼻咽癌患者鼻咽部肿瘤组织中的VEGF及CXCR4阳性表达率分别为62.9%(22 35)和42.9%(15 35),CD34计数为11～92,平均43.2±20.5。无肺转移较有肺转移的患者VEGF的阳性表达率高(78.9%、43.8%,P=0.043),多器官转移较单器官转移的患者CXCR4的表达强度高(62.5%、26.3%,P=0.044)。结论 VEGF表达阳性的患者易发生肺转移;CXCR4强表达的患者易发生多器官转移。Objective To investigate the expression of VEGF, CD34 and CXCR4 and discuss their relationship with clinicopathological parameters in human metastatic nasopharyngeal carcinoma （NPC）. Methods Between March 2003 and May 2009, the SP immunohistochemistry was performed to detect the expression of VEGF, CD34 and CXCR4 on 35 metastatic NPC specimens, and then the relationship between them and the clinicopathological parameters was analyzed. Results The positive expression rates of VEGF and CXCR4 were 62.9% （22/35） and 42.9% （15/35）, respectively. CD34 was 43.2 ± 20.5 in nasopharyngeal carcinoma tissues. The expression of VEGF was significantly lower in lung metastasis group （43.8%） than in non-metastasis group （78.9%） （P=0.043）. The rate of CXCR4 in metastatic NPC tissue with multiple organ metastasis （62.5%） was significantly higher than that with single organ metastasis （26.3%） （P=0.044）. Conclusion The positive expression rate of VEGF is higher in lung metastasis patients, and high-level expression of CXCR4 is associated with multiple organ metastasis.

关 键 词：转移性鼻咽癌 血管内皮生长因子 抗原 CD34 受体 CXCR4 预后 

分 类 号：R739.63[医药卫生—肿瘤]