己二酸的生物合成  

Biosynthesis of adipic acid

作　　者：韩丽[1] 陈五九[1] 元飞[1] 张媛媛[1] 王钦宏[1] 马延和[1] 

机构地区：[1]中国科学院天津工业生物技术研究所中国科学院系统微生物工程重点实验室,天津300308

出　　处：《生物工程学报》2013年第10期1374-1385,共12页Chinese Journal of Biotechnology

基　　金：国家重点基础研究发展计划(973计划)(No.2011CBA00807);中国科学院科研装备项目(No.YZ201153)资助~~

摘　　要：己二酸是六碳二元羧酸,主要用于生产尼龙、化纤和工程塑料等聚合物,年需求量近300万t。目前己二酸的工业生产主要是利用硝酸氧化芳烃合成己二酸等化学法获得,不仅污染严重,而且是个不可持续的过程,需要发展可行的替代合成方法。近年来,随着合成生物学和代谢工程的发展,绿色、洁净的己二酸生物合成方法逐渐受到人们的关注和重视。文中就己二酸及其前体物的生物合成研究进展进行了综述,并对可能的合成新途径做了展望。Adipic acid is a six-carbon dicarboxylic acid, mainly for the production of polymers such as nylon, chemical fiber and engineering plastics. Its annual demand is close to 3 million tons worldwide. Currently, the industrial production of adipic acid is based on the oxidation of aromatics from non-renewable petroleum resources by chemo-catalytic processes. It is heavily polluted and unsustainable, and the possible alternative method for adipic acid production should be developed. In the past years, with the development of synthetic biology and metabolic engineering, green and clean biotechnological methods for adipic acid production attracted more attention. In this study, the research advances of adipic acid and its precursor production are reviewed, followed by addressing the perspective of the possible new pathways for adipic acid production.

关 键 词：己二酸 顺 顺-粘康酸 生物合成 代谢工程 合成生物学 

分 类 号：TQ225.146[化学工程—有机化工]