胃泌素和生长抑素在胃黏膜损伤修复中的作用  

Role of gastrin and somatostatin in injury and repair of gastric mucosa

作　　者：朱淑琴[1,2] 彭胜男[1] 庄德葆[1] 傅爱香[1] 朱清仙[1] 

机构地区：[1]南昌大学基础医学院,南昌330006 [2]广东省中医院珠海医院,珠海519015

出　　处：《解剖学杂志》2013年第5期880-883,共4页Chinese Journal of Anatomy

基　　金：国家“十一五”科技支撑计划项目（2008bai68b01）;江西省科技支撑计划项目（20111BBG70015-3）

摘　　要：目的：探讨胃泌素和生长抑素在胃黏膜损伤和修复中的作用及大黄酸对胃黏膜损伤的防治作用与机制。方法：采用H—E染色、免疫组织化学和体视学测量方法。结果：对照组大鼠胃黏膜上皮完整，损伤组大鼠胃黏膜局部区域上皮脱落缺失，胃腺体排列疏松，腺细胞萎缩，黏膜层可见出血。保护组和修复组大鼠胃黏膜的损伤较损伤组减轻，还可见少许上皮脱落缺失及黏膜层可见少量出血等情况。损伤组胃泌素的数密度比对照组降低，但保护组和修复组胃泌素的数密度有所恢复。损伤组生长抑素和caspase-3的数密度比对照组增高，但保护组和修复组有所恢复。结论：大黄酸可能通过调节胃泌素和生长抑素的含量，减少凋亡，对胃黏膜损伤产生保护和修复作用。Objective： To investigate the role of gastrin （Gas） and somatostatin （SS） in injury and repair of gastric mucosa and further explore the preventive and therapeutic effeets of rhein on gastric mucosal injury and relevant mechanisms. Methods： The rats were randomly divided into four groups. HE staining, immunohistoehemical and stereological measurement methods were applied. Results.. The gastric mucosa epithelial of the control group rats were integral, the other groups were damaged to different extent. The number density of gastrin-positive cells in the injury group decreased compared with the control group, and that in the protection and repairing groups increased compared with the injury group. The number density of SS- and caspase^3 positive cells were contray to the gastrin-positive cells. Conclusion： Rhein may has protective and repairing effects on gastric mucosal injury by regulating the content of Gas- and SS- positive cells, and then to reduce the apoptosis.

关 键 词：胃泌素 生长抑素 CASPASE-3 大黄酸 大鼠 

分 类 号：R573[医药卫生—消化系统]