活体共聚焦显微镜在感染性角膜炎诊治中的应用  

Role of in vivo confocal microscopy in the management of infectious keratitis

作　　者：梁庆丰[1] 孙旭光[1] LABBE Antoine 

机构地区：[1]首都医科大学附属 北京同仁医院北京同仁眼科 中心北京市眼科研究所 北京市眼科学与视觉科学重点实验室,100005 [2]法国Quinze-Vingts国立眼科医院法国VersaillesSaint-QuentinenYvelines大学AmbroiseParé医院(LABBEAntoine)

出　　处：《中华眼科杂志》2013年第10期951-955,共5页Chinese Journal of Ophthalmology

摘　　要：感染性角膜炎是一种严重的致盲性眼病,早期病原学诊断直接影响着患者的治疗效果.如何快速、准确地鉴别致病病原体目前还是一个挑战.活体共聚焦显微镜检查（IVCM）作为一种非侵入性图像诊断技术,可在细胞水平提供高分辨率图像以显示眼表组织的结构特征.IVCM对感染性角膜炎中棘阿米巴性角膜炎及丝状真菌性角膜炎的诊断具有重要应用价值,已在临床开始推广使用,逐渐成为感染角膜炎随诊的客观依据.本文对近年来IVCM在感染性角膜炎诊治中的应用及进展进行综述.Infectious keratitis remains a severe ocular condition that can lead to irreversible conplications and even blindness.An early diagnosis of an infective microorganism leading to effective treatment may improve the outcome of infectious keratitis.However,the accurate and rapid identification of the infectious agent remains a challenge for the ophthalmologist.In vivo confocal microscopy （IVCM） is a noninvasive imaging technique that provides high-resolution images of ocular surface structures at a cellular level and infectious keratitis represents one of its most important clinical uses.The value of IVCM has been demonstrated in the diagnosis of acanthamoeba and filamentous fungal keratitis.The follow-up of such corneal infections may also be improved by this noninvasive imaging technique.However,the current resolution of IVCM limits its use in cases of bacterial and viral keratitis.

关 键 词：角膜炎 显微镜检查 共焦 细菌 病毒 真菌 棘阿米巴属 

分 类 号：R772.21[医药卫生—眼科]