胰高血糖素样肽2与溃疡性结肠炎相关性研究  

Relationship between Glucagon-like peptide 2 and ulcerative colitis

作　　者：宋胜杰[1] 孙立影[1] 徐洪雨[1] 

机构地区：[1]哈尔滨医科大学附属第一医院消化内科,黑龙江哈尔滨150001

出　　处：《胃肠病学和肝病学杂志》2013年第10期959-962,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：溃疡性结肠炎是直肠与结肠部位一种原因未明、可能与自身免疫有关的炎症性肠病,其病因仍然不十分明确。溃疡性结肠炎的药物治疗主要是抗炎和调节免疫反应,近年来细胞因子和生物制剂的研究与应用受到重视。胰高血糖素样肽2(GLP-2)是新近发现的肠上皮特异性生长因子,通过作用于特异性G蛋白偶联受体(GLP-2受体)来保护肠道细胞。GLP-2有利于肠黏膜的再生和修复,抑制炎症介质的表达,并能恢复和维持小肠黏膜上皮屏障的完整性,进而促进肠功能的恢复,这为溃疡性结肠炎治疗提供了新的思路和方法。Ulcerative colitis is a kind of bowel diseases that involved rectum and colon, currently whose etiology is still not very clear. It may be related with autoimmune inflammatory. Drug treatments of ulcerative colitis are mainly an- ti-inflammatory and regulating immune response. In recent years, we begin to pay attention to the research and applica- tion of cell factor and biological agents. Glucagon-like peptide 2 （GLP-2） is the latest discovered intestinal epithelium specific growth factor, which protects the intestinal cells through the effect on specific G protein coupled receptor （GLP- 2 receptor）. GLP-2 is beneficial to intestinal mucosa of regeneration and repair, inhibiting inflammation medium expres- sion, and it can restore and maintain the integrity of the small intestinal mucosa epithelial barrier, and then promote the recovery of intestinal function. This may provides a new train of thought and method treatment of ulcerative colitis.

关 键 词：胰高血糖素样肽-2 胃肠激素 溃疡性结肠炎 肠道保护 治疗 

分 类 号：R574.62[医药卫生—消化系统]