蛛网膜下腔出血患者肠黏膜屏障的改变  

Changes of intestinal mucosal barrier in patients with subarachnoid hemorrhage

作　　者：王德超[1] 苏立凯[1] 王惠凌[1] 

机构地区：[1]河北大学附属医院神经内科,保定071000

出　　处：《临床神经病学杂志》2013年第5期381-382,共2页Journal of Clinical Neurology

摘　　要：目的探讨蛛网膜下腔出血（SAH）患者肠黏膜屏障的改变。方法采用双抗体夹心酶联免疫吸附法对42例SAH患者进行血清D哥L酸（D—LAC）、二胺氧化酶（DAO）检测，结果与30名正常对照者比较。结果SAH组患者各时间点血清D—LAC、DAO水平明显高于正常对照组（均P〈0．01）。SAH组患者血清D—LAC、DAO水平在发病后2h、8h、24h、72h和1周这5个不同时间点间比较，差异无统计学意义。SAH组患者血清D—LAC、DAO水平在发病后2周时明显降低（P〈0．05～0．01）。结论SAH患者存在肠黏膜屏障功能损伤。Objective To study the changes of intestinal mucosal barrier in patients with subarachnoid hemorrhage （SAH）. Methods The serum D-lactic acid （D-LAC） and diamine oxidase （DAO） of 42 SAH patients were detected by double antibody sandwich enzyme linked immunosorbent assay, and the results were compared with 30 normal controls. Results The serum D-LAC and DAO levels in SAH group at each time points were significantly higher than that in normal control group （all P 〈 0. 01 ）. The differences of the serum D-LAC and DAO levels among the 5 different time points of 2 h, 8 h, 24 h, 72 h and 1 week after onset were no statistical significance. The serum D-LAC and DAO levels in SAH group were significantly decreased since 2 weeks after onset （ P 〈 0. 05 - 0.01 ）. Conclusion The function of intestinal mucosal barrier injured is existed in SAH patients.

关 键 词：蛛网膜下腔出血 肠黏膜屏障 D-乳酸 二胺氧化酶 

分 类 号：R743.35[医药卫生—神经病学与精神病学]