厦门市海沧区结直肠癌筛查结果分析  

Analysis of colorectal screening results in the Haicang district of Xiamen city

作　　者：黄连江[1] 袁玉涛[1] 何洁[2] 张晶[1] 颜松龄[3] 李小华[2] 庄建民[3] 梁小亮[1] 

机构地区：[1]厦门市第二医院检验科,厦门361021 [2]厦门市第二医院消化内镜科 [3]厦门市第二医院普通外科

出　　处：《实用肿瘤学杂志》2013年第5期406-409,共4页Practical Oncology Journal

基　　金：厦门市海沧区科技局科技基金项目（350205220084003）

摘　　要：目的通过分析厦门市海沧区结直肠癌的筛查结果，探索筛查的结直肠癌最佳方案，以期达到对结直肠肿瘤的早发现、早诊断和早治疗。方法自2008年12月-2010年10月，采用中国癌症基金会推荐的结直肠癌筛查方案，对海沧区4个行政村40～74岁常住居民结合问卷调查和连续粪便隐血试验（Fecaloccuhbloodtest，FOBT）进行初筛，共8179人，实际接受筛查6380人。高危人群接受全结肠镜检查。结果经问卷调查和FOBT检测，获得结直肠癌高危人群1035例。81．06％的高危者接受全结肠镜检查，结直肠癌和腺瘤息肉及其他病变检出率分别为1．67％和23．96％。问卷调查及FOBT均阳性者结直肠癌检出率显著高于单纯问卷调查阳性者或单纯FOBT阳性者（P〈0．05）；FOBT两次阳性者结直肠癌检出率显著高于FOBT阴性和FOBT单次阳性检出率（P〈0．05）。FOBT检测阳性次数与结直肠癌检出率和腺瘤息肉及其他病变检出率呈线性关系（P〈0．05）。结论调查问卷和连续粪便隐血试验筛查可明显缩小高危人群，大大降低筛查的工作量。Objective We intend to explore the best solution of colorectal cancer screening to achieve early detect, early diagnosis and early therapy for co]oreetal neoplasm by analyzing the results of colorectal screen- ing in Haicang District of Xiamen City. Methods From Dec. 2008 to Oct. 2010, preliminary screening was car- ried out to the inhabitants arranging from 40 to 74 years old in 4 villases of Haicang District combining question- naires and continuous fecal occult blood test（ FOBT）, which is recommended by Chinese Cancer Fundation. High risk people accepted complete colonoscopy. Total number is 8 179 people,among which 6380 people actually re- ceived screening. Results 81.06 percent of 1035 high risk people obtained by questionnaires and FOBT accept- ed complete eolonoseopy. Positive incidence of eolorectal cancer, adenomatous polyps and other lesions were 1. 67% and 23.96% respectively. Coloreetal cancer detection rate was significantly higher in questionnaires and FOBT were both positive than in questionnaire or FOBT positive ahme（ P 〈 O. 05 ）. Colorectal cancer detection rate was significantly higher in FOBT twice positive than in FOBT negative or FOBT once positive（ P 〈 O. 05 ）. Significant linear relationship was observed between times of detection rate in FOBT positive anti eolorectal cancer and adenomatous polyps and other lesions detection rate（ P 〈 O. 05 ）. Conclusion Combining questionnaires and continuous FOBT can significantly concentrate high - risk group colorectal cancer, therefore can greatly reduce the workload of screening.

关 键 词：结直肠癌 筛查 粪便隐血试验 问卷调查 

分 类 号：R735[医药卫生—肿瘤]